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Table 1 Overview of simulation sets used to test power to detect GGI and type I error.

From: Comparison of information-theoretic to statistical methods for gene-gene interactions in the presence of genetic heterogeneity

Model Sample size Number of SNPs Number of Interactions MAF K p h 2
Set 1A: Comparison of KWII to MDRa
1-GH    2 0.5 0.05 0.013
2-GH      0.025  
3-GH 400 10 2 0.25 0.06 0.007
3    1    0.03
4-GH    2 0.1 0.025 0.003
4    1    0.012
Set 1B: Comparison of KWII to RPM b
5A      0.3 0.62
5B       0.3
5C       0.15
6A      0.1 0.22
6B 200 7 1 0.5   0.11
6C       0.056
7A      0.01 0.02
7B       0.01
7C       0.005
Set 2: Comparison of KWII to MDR, RPM, and Logistic Regression Approaches c
1-GH and 7C 600, 1200 & 2400 10 3 0.5 0.037 0.013
Set 3: GAW15 Problem 2 d
1-GH 2400 865 2 0.5 0.05 0.013
2-GH      0.025  
3-GH   865 2 0.25 0.06 0.007
3    1    0.03
4-GH   865 2 0.1 0.025 0.003
4    1    0.012
  1. GH: Genetic Heterogenity; K p = population prevalence; h2 = Broad sense heritability;
  2. a Penetrance is modeled as in Table 2 [16]
  3. b Penetrance is modeled as in Table 3 [2]
  4. c Kp values for Interactions 1 and 2 are each 0.05 (penetrance table from Model 1-GH from [16]) and for interaction 3 Kp is 0.01 (penetrance table from Model 7C from [2])
  5. d[27]