Table 1 Genes associated (P < 0.05) with aggressiveness and representative neurological pathways in male zebrafish, based on analyses performed using data from hypothalamus and telencephalon of dominant (high aggression) and subordinate (low aggression) males sampled on day 1 of interaction.
From: Unravelling the neurophysiological basis of aggression in a fish model
Region of brain | GenBank accession no. | Gene | Description | Pathway | Fold-increase in dominants (mean ± SEM) | P-value |
|---|---|---|---|---|---|---|
Genes overexpressed in dominants | ||||||
Hypothalamus | NM_178293 | avpl | arginine vasopressin-like | HNS | 4.31 ± 1.60 | 0.038 |
|  | XM_695195 | avplr1b | arginine vasopressin-like receptor 1b | HNS | 1.56 ± 0.18 | 0.020 |
|  | NM_178291 | oxtl | oxytocin-like | HNS | 3.77 ± 1.01 | 0.023 |
|  | NM_001001843 | tph1b | tryptophan hydroxylase 1b | 5-HT | 2.98 ± 0.69 | 0.017 |
|  | EH441641 | htr1a | 5-hydroxytryptamine (serotonin) receptor 1A | 5-HT | 1.59 ± 0.21 | 0.027 |
|  | AF435965 | sst1 | somatostatin 1 | Somatostatin | 1.56 ± 0.21 | 0.048 |
|  | XM_691574 | sstr1 | somatostatin receptor 1 | Somatostatin | 1.67 ± 0.22 | 0.019 |
|  | AF075384 | th | tyrosine hydroxylase | Dopamine | 1.94 ± 0.33 | 0.021 |
|  | AY333792 | drd2c | dopamine receptor d2c | Dopamine | 1.58 ± 0.22 | 0.044 |
|  | EF150846 | hdc | histidine decarboxylase | Histamine | 1.88 ± 0.17 | 0.003 |
|  | NM_001045338 | hrh2 | histamine receptor h2 | Histamine | 1.73 ± 0.28 | 0.046 |
|  | NM_001007379 | crh | corticotropin releasing hormone | HPI | 1.75 ± 0.26 | 0.033 |
|  | EF567112 | nr3c1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | HPI | 1.66 ± 0.25 | 0.035 |
|  | NM_131074 | npy | neuropeptide y | HPI | 1.67 ± 0.19 | 0.024 |
|  | AJ304429 | gnrh3 | gonadotropin-releasing hormone 3 | HPG | 2.16 ± 0.34 | 0.015 |
|  | NM_180966 | esr2a | estrogen receptor 2a | HPG | 1.52 ± 0.18 | 0.030 |
|  | NM_001083123 | ar | androgen receptor | HPG | 1.96 ± 0.30 | 0.010 |
Telencephalon | NM_131755 | slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Dopamine | 2.25 ± 0.45 | 0.029 |
|  | AJ304429 | gnrh3 | gonadotropin-releasing hormone 3 | HPG | 2.37 ± 0.50 | 0.025 |
|  | AJ414566 | esr2b | estrogen receptor 2b | HPG | 1.63 ± 0.21 | 0.045 |
Genes overexpressed in subordinates | ||||||
Telencephalon | NM_183067 | drd3 | dopamine receptor d3 | Dopamine | 0.56 ± 0.09 | 0.041 |
|  | NM_001045338 | hrh2 | histamine receptor h2 | Histamine | 0.38 ± 0.05 | 0.010 |
|  | NM_001007379 | crh | corticotropin releasing hormone | HPI | 0.56 ± 0.07 | 0.044 |
|  | EF567112 | nr3c1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | HPI | 0.62 ± 0.05 | 0.023 |
|  | NM_131074 | npy | neuropeptide y | HPI | 0.68 ± 0.08 | 0.029 |