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Table 1 Genes associated (P < 0.05) with aggressiveness and representative neurological pathways in male zebrafish, based on analyses performed using data from hypothalamus and telencephalon of dominant (high aggression) and subordinate (low aggression) males sampled on day 1 of interaction.

From: Unravelling the neurophysiological basis of aggression in a fish model

Region of brain GenBank accession no. Gene Description Pathway Fold-increase in dominants (mean ± SEM) P-value
Genes overexpressed in dominants
Hypothalamus NM_178293 avpl arginine vasopressin-like HNS 4.31 ± 1.60 0.038
  XM_695195 avplr1b arginine vasopressin-like receptor 1b HNS 1.56 ± 0.18 0.020
  NM_178291 oxtl oxytocin-like HNS 3.77 ± 1.01 0.023
  NM_001001843 tph1b tryptophan hydroxylase 1b 5-HT 2.98 ± 0.69 0.017
  EH441641 htr1a 5-hydroxytryptamine (serotonin) receptor 1A 5-HT 1.59 ± 0.21 0.027
  AF435965 sst1 somatostatin 1 Somatostatin 1.56 ± 0.21 0.048
  XM_691574 sstr1 somatostatin receptor 1 Somatostatin 1.67 ± 0.22 0.019
  AF075384 th tyrosine hydroxylase Dopamine 1.94 ± 0.33 0.021
  AY333792 drd2c dopamine receptor d2c Dopamine 1.58 ± 0.22 0.044
  EF150846 hdc histidine decarboxylase Histamine 1.88 ± 0.17 0.003
  NM_001045338 hrh2 histamine receptor h2 Histamine 1.73 ± 0.28 0.046
  NM_001007379 crh corticotropin releasing hormone HPI 1.75 ± 0.26 0.033
  EF567112 nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) HPI 1.66 ± 0.25 0.035
  NM_131074 npy neuropeptide y HPI 1.67 ± 0.19 0.024
  AJ304429 gnrh3 gonadotropin-releasing hormone 3 HPG 2.16 ± 0.34 0.015
  NM_180966 esr2a estrogen receptor 2a HPG 1.52 ± 0.18 0.030
  NM_001083123 ar androgen receptor HPG 1.96 ± 0.30 0.010
Telencephalon NM_131755 slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Dopamine 2.25 ± 0.45 0.029
  AJ304429 gnrh3 gonadotropin-releasing hormone 3 HPG 2.37 ± 0.50 0.025
  AJ414566 esr2b estrogen receptor 2b HPG 1.63 ± 0.21 0.045
Genes overexpressed in subordinates
Telencephalon NM_183067 drd3 dopamine receptor d3 Dopamine 0.56 ± 0.09 0.041
  NM_001045338 hrh2 histamine receptor h2 Histamine 0.38 ± 0.05 0.010
  NM_001007379 crh corticotropin releasing hormone HPI 0.56 ± 0.07 0.044
  EF567112 nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) HPI 0.62 ± 0.05 0.023
  NM_131074 npy neuropeptide y HPI 0.68 ± 0.08 0.029