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Table 2 Genes associated (P < 0.05) with aggressiveness in female zebrafish, based on analyses performed using data from the hypothalamus and telencephalon of dominant (high aggression) and subordinate (low aggression) females sampled on day 1 of interaction.

From: Unravelling the neurophysiological basis of aggression in a fish model

Region of brain GenBank accession no. Gene Description Pathway Fold-increase in dominants (mean ± SEM) P-value
Genes overexpressed in dominants
Hypothalamus NM_178293 avpl arginine vasopressin-like HNS 3.89 ± 0.82 0.014
  XM_695195 avplr1b arginine vasopressin-like receptor 1b HNS 3.04 ± 0.82 0.022
  NM_178291 oxtl oxytocin-like HNS 3.19 ± 0.58 0.016
  NM_214795 tph2 tryptophan hydroxylase 2 5-HT 2.83 ± 0.46 0.005
  EH441641 htr1a 5-hydroxytryptamine (serotonin) receptor 1A 5-HT 2.89 ± 0.72 0.037
  DQ285098 slc6a4a solute carrier family 6 (neurotransmitter transporter, serotonin), member 4a 5-HT 3.44 ± 0.57 0.001
  NM_212827 maoa monoamine oxidase a 5-HT 3.52 ± 0.82 0.014
  AF435965 sst1 somatostatin 1 Somatostatin 1.77 ± 0.28 0.042
  BI473045 sst3 somatostatin 3 Somatostatin 3.61 ± 1.00 0.002
  AF075384 th tyrosine hydroxylase Dopamine 2.10 ± 0.40 0.038
  NM_131755 slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Dopamine 2.56 ± 0.56 0.030
  NM_001045338 hrh2 histamine receptor h2 Histamine 1.96 ± 0.30 0.029
  NM_131660 nos1 nitric oxide synthase 1 (neuronal) Nitric oxide 2.51 ± 0.51 0.022
  NM_001007379 crh corticotropin releasing hormone HPI 1.88 ± 0.29 0.025
  EF567112 nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) HPI 2.02 ± 0.38 0.040
  NM_131074 npy neuropeptide y HPI 4.37 ± 0.95 0.002
  AJ304429 gnrh3 gonadotropin-releasing hormone 3 HPG 2.78 ± 0.67 0.044
  NM_131642 cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b HPG 2.95 ± 0.57 0.001
  AB037185 esr1 estrogen receptor 1 HPG 3.02 ± 0.80 0.005
  NM_180966 esr2a estrogen receptor 2a HPG 2.80 ± 0.55 0.022
  NM_001083123 ar androgen receptor HPG 2.61 ± 0.52 0.014
Telencephalon XM_695195 avplr1b arginine vasopressin-like receptor 1b HNS 1.80 ± 0.22 0.031
  AF548566 tph1a tryptophan hydroxylase 1a 5-HT 4.61 ± 0.74 0.001
  NM_214795 tph2 tryptophan hydroxylase 2 5-HT 3.09 ± 0.55 0.016
  BI473045 sst3 somatostatin 3 Somatostatin 1.92 ± 0.33 0.029
  NM_131755 slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Dopamine 2.48 ± 0.48 0.017
  AJ304429 gnrh3 gonadotropin-releasing hormone 3 HPG 1.87 ± 0.35 0.048
  AJ414566 esr2b estrogen receptor 2b HPG 1.79 ± 0.27 0.029