miR-7 | Expressed in pancreatic adult and fetal endocrine cells [18, 19, 30] |
miR-375 | Negative regulator of glucose-induced insulin secretion through myothrophin regulation [15]. miR-375 K/O mice are hyperglycemic -more alpha cells; less beta-cells- [17]. Regulation of PI3 pathway by regulation of PDK1 in insulinoma cells [31]. The miR-375 gene promoter directs expression selectively to endocrine pancreas [32]. |
miR-9 | Expressed at high levels during islet development [19]. Target of transcription factor Onecut-2 impairing glucose-induced insulin secretion in insulinoma cells. |
miR-195; miR-16 miR-15a; miR-15b | Role in pancreatic regeneration, possibly by targeting Ngn3 [22]. |
miR-124a | Regulation of insulin secretion machinery and transcription factor Foxa2 in insulinoma cells [21, 33]. |
miR-218 | Expressed in mouse early fetal pancreas, controls the liver and pancreatic development regulator Onecut-2 in liver embryonic cells [34]. |
miR-484; miR-107; miR-30d | High glucose down-regulates their expression in insulinoma cells [35]. |
miR-146a | Increased expression in islets from db/db obese mice, contributes to fatty acids-induced beta-cell dysfunction [36]. Pro-inflammatory cytokines induce its expression in human islet and MIN6 cells [37]. |
miR-29a | Over-expression induced insulin resistance in 3T3 adipocytes [38]. |
miR-503 | miR-503 is expressed in a pattern similar to that of miR-375 in a mouse progenitor cells at e14.5 pancreas [13]. |
miR-376a | Expressed at high levels during islet development [19]. |
miR-21; miR-34a | Pro-inflammatory cytokines induce its expression in human islet and MIN6 cells [37]. miR-34a also contributes to fatty acids-induced beta-cell dysfunction [36]. |
miR-96 | Increases mRNA and protein levels of granulophilin, a negative regulator of insulin exocytosis [33]. |