Figure 6

Identification of putative signaling regulators for immune-modification. Key node analysis in the TRANSPATH database for putative unique signaling master regulator/molecule at 0.5 h with significant inhibition of expression (≥3-fold decrease) in LPS-induced THP-1 cells co-treated with (A) shikonin, (B) emodin, or (C) BF/S+L/Ep at 12 h. Less than four hierarchical levels of regulation were accepted and selected. Pink circle: the putative master regulator/molecule; green box: the ratio of gene expression seen with the phytocompounds plus LPS compared to LPS only; gray circle: assigned molecule in the putative pathway; ↑: activation; ⊥: inhibition.