Figure 2
From: Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated
Genome-wide conserved consensus motifs (predicted TFBS) are hyper-methylated in human hearts and sperm. Methylation scores were determined across the genome for hearts and sperm using BATMAN [21]. The profiles of these scores (A: hearts, B: sperm) were plotted against locations of conserved consensus motifs for 106 transcription factor families centred on the predicted TF binding site (based on co-ordinates obtained from the UCSC genome web browser: TFBS Conserved track; "set 1", N = 3,749,417 locations). Methylation profile at random genomic locations was analyzed as a negative control and reflects a "neutral" methylation pattern at these locations ("set 2", N = 20,982).