|
Accession numbers
|
Gene symbols
|
Fold change
|
|---|
| | |
LEC
|
Limbus
|
Cornea
|
|---|
|
WNT signalling pathway
|
|
NM_016269
|
LEF1
|
(1.2)
|
-
|
-
|
|
NM_006261
|
CDH1
|
(5.3)
|
-
|
(-5.8)
|
|
NM_013263
|
BRD7
|
(-4.0)
|
(1.8)
|
(4.0)
|
|
NM_001892
|
CSNK1A1
|
-
|
(4.6)
|
-
|
|
AF267864
|
TBL1XR1
|
-
|
-
|
(1.9)
|
|
NM_003507
|
FZD7
|
-
|
-
|
(2.0)
|
|
NM_022825
|
PORCN
|
-
|
-
|
(2.0)
|
|
NM_018890
|
RAC1
|
(-3.0)
|
-
|
(3.0)
|
|
NM_001320
|
CSNK2B
|
(-2.6)
|
-
|
(2.6)
|
|
NM_014248
|
RBX1
|
(5.6)
| |
(-5.6)
|
|
Notch Signalling pathway
|
|
NM_014276
|
RBPJL
|
(-3.9)
|
-
|
(3.9)
|
|
NM_005524
|
HES1
|
(-1.5)
|
-
|
(2.1)
|
|
NM_203283
|
RBPJ
|
-
|
-
|
(4.6)
|
|
NM_033632
|
FBXW7
|
(-6.1)
|
-
|
(6.1)
|
|
JAK/STAT Signalling pathway
|
|
NM_004232
|
SOCS6
|
-
|
-
|
(3.9)
|
|
U52912
|
LEPR
|
(-3.4)
|
(-2.2)
|
(3.4)
|
|
U52914
|
LEPR
|
-
|
-
|
(2.3)
|
|
AJ271736
|
IL9R
|
-
|
(-4.2)
|
(4.2)
|
|
NM_000565
|
IL6R
|
-
|
(-8.7)
|
(8.7)
|
|
NM_003150
|
STAT3
|
-
|
-
|
(1.7)
|
|
NM_000297
|
PKD2
|
(-2.8)
|
-
|
(2.8)
|
|
NM_014432
|
IL20RA
|
(-4.2)
|
-
|
(4.2)
|
|
TGF-Beta Signalling pathways
|
|
NM_002165
|
ID1
|
(-3.6)
|
(1.5)
|
(3.6)
|
|
NM_006350
|
FST
|
-
|
-
|
(2.4)
|
|
NM_014248
|
RBX1
|
(5.6)
|
-
|
(-5.6)
|
|
NM_002165
|
ID1
|
(-3.6)
|
(1.5)
|
(3.6)
|
|
BMP Signalling pathway
|
|
AL096865
|
RUNX2
|
(-2.4)
|
-
|
(2.4)
|
|
NM_006350
|
FST
|
-
|
-
|
(2.4)
|
|
Hedgehog signalling pathway (HH)
|
|
NM_001892
|
CSNK1A1
|
-
|
(4.5)
|
-
|
|
NM_016004
|
IFT52
|
-
|
(2.5)
|
-
|
|
NM_005870
|
SAP18
|
(-5.3)
|
(-3.7)
|
(6.2)
|
- The differentially expressed SC signalling molecules in the OS epithelial regions were identified with KEGGS pathways and reactome. Numbers in brackets are fold change. Negative values indicate downregulated and positive values are upregulated gene expression. No values denote absence of gene expression in the region.
