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Table 5 Stem cell signaling pathway genes in OS epithelial regions

From: Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics

Accession numbers Gene symbols Fold change
   LEC Limbus Cornea
WNT signalling pathway
NM_016269 LEF1 (1.2) - -
NM_006261 CDH1 (5.3) - (-5.8)
NM_013263 BRD7 (-4.0) (1.8) (4.0)
NM_001892 CSNK1A1 - (4.6) -
AF267864 TBL1XR1 - - (1.9)
NM_003507 FZD7 - - (2.0)
NM_022825 PORCN - - (2.0)
NM_018890 RAC1 (-3.0) - (3.0)
NM_001320 CSNK2B (-2.6) - (2.6)
NM_014248 RBX1 (5.6)   (-5.6)
Notch Signalling pathway
NM_014276 RBPJL (-3.9) - (3.9)
NM_005524 HES1 (-1.5) - (2.1)
NM_203283 RBPJ - - (4.6)
NM_033632 FBXW7 (-6.1) - (6.1)
JAK/STAT Signalling pathway
NM_004232 SOCS6 - - (3.9)
U52912 LEPR (-3.4) (-2.2) (3.4)
U52914 LEPR - - (2.3)
AJ271736 IL9R - (-4.2) (4.2)
NM_000565 IL6R - (-8.7) (8.7)
NM_003150 STAT3 - - (1.7)
NM_000297 PKD2 (-2.8) - (2.8)
NM_014432 IL20RA (-4.2) - (4.2)
TGF-Beta Signalling pathways
NM_002165 ID1 (-3.6) (1.5) (3.6)
NM_006350 FST - - (2.4)
NM_014248 RBX1 (5.6) - (-5.6)
NM_002165 ID1 (-3.6) (1.5) (3.6)
BMP Signalling pathway
AL096865 RUNX2 (-2.4) - (2.4)
NM_006350 FST - - (2.4)
Hedgehog signalling pathway (HH)
NM_001892 CSNK1A1 - (4.5) -
NM_016004 IFT52 - (2.5) -
NM_005870 SAP18 (-5.3) (-3.7) (6.2)
  1. The differentially expressed SC signalling molecules in the OS epithelial regions were identified with KEGGS pathways and reactome. Numbers in brackets are fold change. Negative values indicate downregulated and positive values are upregulated gene expression. No values denote absence of gene expression in the region.