Genome-wide analysis of the effect of histone modifications on the coexpression of neighboring genes in Saccharomyces cerevisiae

Table 1 The correlation between expression change and acetylation change in neighboring genes

	Correlation with neighboring ORFs⁺	p-value*	Correlation with neighboring promoters⁺	p-value*
ΔH3K14ac
up4	0.025	0.0655	0.026	0.0846
up3	0.042	0.0016	0.044	0.0035
up2	0.080	2.27E-06	0.066	2.51E-08
up1	0.267	2.77E-48	0.203	2.84E-81
down1	0.082	1.93E-08	0.078	6.39E-09
down2	0.031	0.0832	0.024	0.0300
down3	-0.003	0.3776	0.012	0.8123
down4	-0.011	0.1277	0.021	0.4523
ΔH4ac
up4	0.016	0.1245	0.022	0.2631
up3	0.033	0.0008	0.047	0.0207
up2	0.049	7.87E-08	0.075	6.33E-04
up1	0.247	7.42E-40	0.184	1.32E-69
down1	0.070	5.11E-10	0.086	7.75E-07
down2	0.025	0.0379	0.029	0.0828
down3	-0.011	0.3898	0.012	0.4501
down4	0.002	0.1063	0.023	0.8984

+: the correlations were measured by the Pearson Correlation Coefficient between the gene expression change and the acetylation change of up4 ~ down4 gene in their ORFs and promoter regions, respectively.
*: p-value is the significant of the correlation coefficient by compared with the random.

ISSN: 1471-2164