Table 1 Different expression of genes in spleens after S. suis infection 3 days
From: Response of swine spleen to Streptococcus suis infection revealed by transcription analysis
| Function classification | ENTREZ GENE_ID | Description | Fold change | Q-value (%) |
|---|---|---|---|---|
| Inflammatory response | ||||
| 929 | CD14 Antigen | 3.4 | 1.222 | |
| 6279 | S100 Calcium binding protein A8 | 19.3 | 1.508 | |
| 6280 | S100 Calcium binding protein A9 | 16.1 | 0 | |
| 3588 | Interleukin 10 receptor, beta | 2.7 | 3.911 | |
| 5743 | Prostaglandin-Endoperoxide synthase 2 | 4.7 | 7.146 | |
| 7057 | Thrombospondin 1 | 2.4 | 6.387 | |
| 3576 | Interleukin 8 | 5.6 | 6.387 | |
| 9547 | Chemokine (C-X-C Motif) Ligand 14 | 2.0 | 8.898 | |
| 6283 | S100 Calcium binding protein A12 | 18.6 | 0 | |
| 2908 | Nuclear receptor subfamily 3, group C, member 1 | 0.5 | 6.882 | |
| 6363 | Chemokine (C-C Motif) Ligand 19 | 2.2 | 1.508 | |
| 7097 | Toll-like receptor 2 | 2.0 | 6.387 | |
| 2920 | Chemokine (C-X-C Motif) Ligand 2 | 7.3 | 3.385 | |
| 246 | Arachidonate 15-Lipoxygenase | 0.2 | 2.181 | |
| 7052 | Transglutaminase 2 | 2.1 | 6.387 | |
| 9332 | CD163 antigen | 11.7 | 0 | |
| 6288 | Serum amyloid A1 | 6.4 | 1.222 | |
| 3553 | Interleukin 1, beta | 16.7 | 6.387 | |
| 3569 | Interleukin 6 (Interferon, Beta 2) | 4.8 | 6.387 | |
| 56729 | Resistin | 3.7 | 7.146 | |
| Response to stress | ||||
| 1153 | Cold inducible rna binding protein | 0.43 | 5.612 | |
| 3320 | Heat shock protein 90Kda alpha class A member 1 | 3.2 | 8.898 | |
| 6916 | Thromboxane A synthase 1 | 2.6 | 3.911 | |
| 10963 | Stress-induced-phosphoprotein 1 | 2.5 | 0 | |
| 130872 | AHA1, activator of heat shock 90Kda protein ATPase homolog 2 | 2.6 | 1.508 | |
| 3337 | Dnaj (Hsp40) homolog, subfamily B, member 1 | 2.8 | 1.222 | |
| 871 | Serpin peptidase inhibitor, clade H (Heat Shock Protein 47), member 1 | 2.7 | 1.222 | |
| 10808 | Heat shock 105Kda/110Kda protein 1 | 3.3 | 0 | |
| 3301 | Dnaj (Hsp40) homolog, subfamily A, member 1 | 2.4 | 0 | |
| 3304 | Heat Shock 70Kda Protein 1A | 11.1 | 0 | |
| Coagulation | ||||
| 5328 | Plasminogen activator, urokinase | 2.0 | 6.387 | |
| 2162 | Coagulationfactor XIII, A1 polypeptide | 6.8 | 3.385 | |
| Signal transduction | ||||
| 9465 | A kinase anchor protein 7 | 0.5 | 6.698 | |
| 8519 | Interferon induced transmembrane protein 1 | 2.0 | 6.387 | |
| 115265 | Dna-damage-inducible transcript 4-like | 0.3 | 2.181 | |
| 9770 | Ras association (Ralgds/Af-6) domain family 2 | 2.4 | 6.387 | |
| 9510 | Adamm etallopeptidase with thrombospondin type 1 motif, 1 | 2.3 | 0 | |
| 1363 | Carboxypeptidase E | 0.44 | 6.698 | |
| 54210 | Triggering receptor expressed on myeloid cells 1 | 3.2 | 6.387 | |
| 9289 | G protein-coupled receptor 56 | 0.46 | 6.698 | |
| 7043 | Transforming growth factor, beta 3 | 2.1 | 4.116 | |
| Transcription | ||||
| 2353 | V-Fos fbj murine osteosarcoma viral oncogene homolog | 2.8 | 3.911 | |
| 84969 | Chromosome 20 open reading frame 100 | 0.3 | 2.541 | |
| 55885 | Lim domain only 3 | 0.3 | 2.181 | |
| 3726 | Jun B proto-oncogene | 2.6 | 7.146 | |
| 91 | Activin a receptor, type ib | 3.4 | 1.222 | |
| 116448 | Oligodendrocyte transcription factor 1 | 2.4 | 6.387 | |
| 79365 | Basic helix-loop-helix domain containing, class B, 3 | 0.4 | 2.181 | |
| 64919 | B-cell cll/lymphoma 11B | 0.5 | 2.181 | |
| 23635 | Single-stranded dna binding protein 2 | 0.4 | 2.541 | |
| 23414 | Zinc finger protein, multitype 2 | 0.5 | 6.698 | |
| 7552 | Zinc finger protein 6 (Cmpx1) | 0.5 | 3.385 | |
| 6920 | Transcription elongation factor A (SII), 3 | 2.2 | 6.387 | |
| 4783 | Nuclear factor, interleukin 3 regulated | 2.4 | 3.911 | |
| 1052 | CCAAT/Enhancer binding protein (C/EBP), delta | 3.1 | 0 | |
| Cell adhesion | ||||
| 6401 | Selectin E | 3.5 | 1.222 | |
| 8174 | Mucosal vascular addressin cell adhesion molecule 1 | 2.3 | 6.387 | |
| 5067 | Contactin 3 | 0.5 | 6.794 | |
| 4867 | Nephronophthisis 1 (Juvenile) | 0.4 | 3.911 | |
| 1462 | Chondroitin sulfate proteoglycan 2 (Versican) | 9.1 | 0 | |
| 960 | CD44 antigen | 2.3 | 2.541 | |
| Ubiquitin cycle | ||||
| 115123 | Membrane-associated ring finger (C3HC4) 3 | 4.4 | 1.222 | |
| 7317 | Ubiquitin-activating enzyme E1 | 0.4 | 2.181 | |
| 11274 | Ubiquitin specific peptidase 18 | 0.4 | 6.698 | |
| 9666 | Zinc finger daz interacting protein 3 | 0.5 | 6.882 | |
| Transport | ||||
| 6556 | Solute carrier family 11, member 1 | 4.0 | 2.051 | |
| 4057 | Lactotransferrin | 5.9 | 3.385 | |
| 1356 | Ceruloplasmin (Ferroxidase) | 2.3 | 2.541 | |
| 1410 | Crystallin, alpha B | 2.8 | 6.387 | |
| 283652 | Solute carrier family 24, member 5 | 0.4 | 2.181 | |
| 54843 | Synaptotagmin-like 2 | 0.4 | 6.698 | |
| 6947 | Haptocorrin | 8.9 | 0 | |
| 3949 | Low density lipoprotein receptor | 2.1 | 5.612 | |
| 3043 | Hemoglobin, beta | 0.4 | 6.698 | |
| 3042 | Hemoglobin, alpha pseudogene 2 | 0.2 | 2.181 | |
| 3040 | Hemoglobin, alpha 1 | 0.2 | 2.181 | |
| 2554 | Gamma-aminobutyric acid (Gaba) a receptor, alpha 1 | 0.3 | 3.911 | |
| 2288 | Fk506 binding protein 4, 59Kda | 2.2 | 1.222 | |
| 6557 | Solute carrier family 12, member 1 | 0.4 | 6.882 | |
| 152789 | Janus kinase and microtubule interacting protein 1 | 0.5 | 6.794 | |
| Nucleic acid metabolic process | ||||
| 401251 | Muts homolog 5 | 0.5 | 6.698 | |
| 56952 | Phosphoribosyl transferase domain | 0.4 | 2.181 | |
| 51251 | 5'-Nucleotidase, cytosolic Iii | 0.4 | 6.698 | |
| 10492 | Synaptotagmin binding, cytoplasmic rna interacting protein | 0.4 | 4.116 | |
| 8347 | Histone 1,H2bd | 2.6 | 6.387 | |
| 8334 | Histone 1, H2ac | 5.6 | 1.222 | |
| 6430 | Splicing factor, arginine/serine-rich 5 | 0.5 | 0 | |
| 4302 | Myeloid/Lymphoid or mixed-lineage leukemia translocated to, 6 | 0.4 | 6.882 | |
| Response to stimulus | ||||
| 5806 |
Pentraxin-related gene, rapidly induced by il-1 beta | 14.1 | 1.222 | |
| 6372 | Chemokine (C-X-C motif) ligand 6 | 5.5 | 1.222 | |
| 64135 | Interferon induced with helicase c domain 1 | 0.4 | 6.698 | |
| 3240 | Haptoglobin | 4.6 | 0 | |
| 6648 | Superoxide dismutase 2, mitochondrial | 4.6 | 1.508 | |
| 1843 | Dual specificity phosphatase 1 | 2.1 | 6.387 | |
| Cell differentiation/development | ||||
| 58189 | Wap four-disulfide core domain 1 | 2.1 | 1.222 | |
| 9531 | Bcl2-associated athanogene 3 | 3.7 | 0 | |
| 51454 | Gulp, engulfment adaptor ptb domain containing1 | 0.4 | 2.181 | |
| 212 | Aminolevulinate, delta-, synthase 2 | 0.4 | 6.698 | |
| 2012 | Epithelial membrane protein 1 | 2.0 | 7.146 | |
| 79689 | Steap family member 4 | 2.8 | 3.911 | |
| 9021 | Suppressor of cytokine signaling 3 | 2.4 | 3.385 | |
| 5270 | Serpin peptidase inhibitor, clade E, member 2 | 2.3 | 3.385 | |
| 1946 | Ephrin-A5 | 0.4 | 3.911 | |
| 85444 | Leucine rich repeat and coiled-coil domain containing 1 | 0.5 | 5.612 | |
| 54873 | Palmdelphin | 0.4 | 5.612 | |
| 10439 | Olfactomedin 1 | 3.3 | 6.387 | |
| Carbohydrate metabolic process | ||||
| 4199 | Malic enzyme 1, NADP(+)-dependent, cytosolic | 0.4 | 3.911 | |
| 80760 | Inter-alpha (Globulin) inhibitor H5 | 0.3 | 6.698 | |
| 152831 | Klotho beta | 2.5 | 0 | |
| 3101 | Hexokinase 3 (White Cell) | 2.9 | 6.387 | |
| 3099 | Hexokinase 2 | 2.3 | 8.898 | |
| 1116 | Chitinase 3-like 1 | 2.9 | 8.898 | |
| Protein metabolic process | ||||
| 85464 | Slingshot homolog 2 | 2.3 | 1.508 | |
| 51327 | Erythroid associated factor | 0.06 | 0 | |
| 7076 | Timp metallopeptidase inhibitor 1 | 4.4 | 1.222 | |
| 7053 | Transglutaminase 3 | 6.1 | 1.222 | |
| 114907 | F-box protein 32 | 0.4 | 6.794 | |
| 64844 | Membrane-associated ring finger (C3HC4) 7 | 0.5 | 2.181 | |
| 64172 | O-sialoglycoprotein endopeptidase-like 1 | 0.4 | 2.181 | |
| 55466 | Dnaj (Hsp40) homolog, subfamily A, member 4 | 2.7 | 2.541 | |
| 51056 | Leucine aminopeptidase 3 | 2.0 | 8.898 | |
| 2289 | Fk506 binding protein 5 | 2.5 | 6.387 | |
| 26235 | F-box and leucine-rich repeat protein 4 | 0.5 | 6.698 | |
| Nitrogen compound metabolic process | ||||
| 383 | Arginase | 0.2 | 2.181 | |
| 64850 | Alanine-glyoxylate aminotransferase 2-like 1 | 0.2 | 6.882 | |
| 6799 | Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 | 2.0 | 6.387 | |
| 8974 | Procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha polypeptide ii | 3.2 | 6.387 | |
| Others | ||||
| 129446 | Cardiomyopathy associated 3 | 0.3 | 2.181 | |
| 128218 | Transmembrane protein 125 | 2.0 | 8.898 | |
| 57763 | Ankyrin repeat, family A, 2 | 0.4 | 2.181 | |
| 29970 | Schwannomin interacting protein 1 | 0.5 | 6.794 | |
| 23336 | Desmuslin | 0.5 | 6.882 | |
| 590 | Butyrylcholinesterase | 0.5 | 4.116 | |
| 84649 | Diacylglycerol o-acyltransferase homolog 2 | 3.2 | 1.222 | |
| 79887 | Hypothetical protein Flj22662 | 3.5 | 6.387 |