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Table 1 Different expression of genes in spleens after S. suis infection 3 days

From: Response of swine spleen to Streptococcus suis infection revealed by transcription analysis

Function classification ENTREZ GENE_ID Description Fold change Q-value (%)
Inflammatory response     
  929 CD14 Antigen 3.4 1.222
  6279 S100 Calcium binding protein A8 19.3 1.508
  6280 S100 Calcium binding protein A9 16.1 0
  3588 Interleukin 10 receptor, beta 2.7 3.911
  5743 Prostaglandin-Endoperoxide synthase 2 4.7 7.146
  7057 Thrombospondin 1 2.4 6.387
  3576 Interleukin 8 5.6 6.387
  9547 Chemokine (C-X-C Motif) Ligand 14 2.0 8.898
  6283 S100 Calcium binding protein A12 18.6 0
  2908 Nuclear receptor subfamily 3, group C, member 1 0.5 6.882
  6363 Chemokine (C-C Motif) Ligand 19 2.2 1.508
  7097 Toll-like receptor 2 2.0 6.387
  2920 Chemokine (C-X-C Motif) Ligand 2 7.3 3.385
  246 Arachidonate 15-Lipoxygenase 0.2 2.181
  7052 Transglutaminase 2 2.1 6.387
  9332 CD163 antigen 11.7 0
  6288 Serum amyloid A1 6.4 1.222
  3553 Interleukin 1, beta 16.7 6.387
  3569 Interleukin 6 (Interferon, Beta 2) 4.8 6.387
  56729 Resistin 3.7 7.146
Response to stress     
  1153 Cold inducible rna binding protein 0.43 5.612
  3320 Heat shock protein 90Kda alpha class A member 1 3.2 8.898
  6916 Thromboxane A synthase 1 2.6 3.911
  10963 Stress-induced-phosphoprotein 1 2.5 0
  130872 AHA1, activator of heat shock 90Kda protein ATPase homolog 2 2.6 1.508
  3337 Dnaj (Hsp40) homolog, subfamily B, member 1 2.8 1.222
  871 Serpin peptidase inhibitor, clade H (Heat Shock Protein 47), member 1 2.7 1.222
  10808 Heat shock 105Kda/110Kda protein 1 3.3 0
  3301 Dnaj (Hsp40) homolog, subfamily A, member 1 2.4 0
  3304 Heat Shock 70Kda Protein 1A 11.1 0
Coagulation     
  5328 Plasminogen activator, urokinase 2.0 6.387
  2162 Coagulationfactor XIII, A1 polypeptide 6.8 3.385
Signal transduction     
  9465 A kinase anchor protein 7 0.5 6.698
  8519 Interferon induced transmembrane protein 1 2.0 6.387
  115265 Dna-damage-inducible transcript 4-like 0.3 2.181
  9770 Ras association (Ralgds/Af-6) domain family 2 2.4 6.387
  9510 Adamm etallopeptidase with thrombospondin type 1 motif, 1 2.3 0
  1363 Carboxypeptidase E 0.44 6.698
  54210 Triggering receptor expressed on myeloid cells 1 3.2 6.387
  9289 G protein-coupled receptor 56 0.46 6.698
  7043 Transforming growth factor, beta 3 2.1 4.116
Transcription     
  2353 V-Fos fbj murine osteosarcoma viral oncogene homolog 2.8 3.911
  84969 Chromosome 20 open reading frame 100 0.3 2.541
  55885 Lim domain only 3 0.3 2.181
  3726 Jun B proto-oncogene 2.6 7.146
  91 Activin a receptor, type ib 3.4 1.222
  116448 Oligodendrocyte transcription factor 1 2.4 6.387
  79365 Basic helix-loop-helix domain containing, class B, 3 0.4 2.181
  64919 B-cell cll/lymphoma 11B 0.5 2.181
  23635 Single-stranded dna binding protein 2 0.4 2.541
  23414 Zinc finger protein, multitype 2 0.5 6.698
  7552 Zinc finger protein 6 (Cmpx1) 0.5 3.385
  6920 Transcription elongation factor A (SII), 3 2.2 6.387
  4783 Nuclear factor, interleukin 3 regulated 2.4 3.911
  1052 CCAAT/Enhancer binding protein (C/EBP), delta 3.1 0
Cell adhesion     
  6401 Selectin E 3.5 1.222
  8174 Mucosal vascular addressin cell adhesion molecule 1 2.3 6.387
  5067 Contactin 3 0.5 6.794
  4867 Nephronophthisis 1 (Juvenile) 0.4 3.911
  1462 Chondroitin sulfate proteoglycan 2 (Versican) 9.1 0
  960 CD44 antigen 2.3 2.541
Ubiquitin cycle     
  115123 Membrane-associated ring finger (C3HC4) 3 4.4 1.222
  7317 Ubiquitin-activating enzyme E1 0.4 2.181
  11274 Ubiquitin specific peptidase 18 0.4 6.698
  9666 Zinc finger daz interacting protein 3 0.5 6.882
Transport     
  6556 Solute carrier family 11, member 1 4.0 2.051
  4057 Lactotransferrin 5.9 3.385
  1356 Ceruloplasmin (Ferroxidase) 2.3 2.541
  1410 Crystallin, alpha B 2.8 6.387
  283652 Solute carrier family 24, member 5 0.4 2.181
  54843 Synaptotagmin-like 2 0.4 6.698
  6947 Haptocorrin 8.9 0
  3949 Low density lipoprotein receptor 2.1 5.612
  3043 Hemoglobin, beta 0.4 6.698
  3042 Hemoglobin, alpha pseudogene 2 0.2 2.181
  3040 Hemoglobin, alpha 1 0.2 2.181
  2554 Gamma-aminobutyric acid (Gaba) a receptor, alpha 1 0.3 3.911
  2288 Fk506 binding protein 4, 59Kda 2.2 1.222
  6557 Solute carrier family 12, member 1 0.4 6.882
  152789 Janus kinase and microtubule interacting protein 1 0.5 6.794
Nucleic acid metabolic process     
  401251 Muts homolog 5 0.5 6.698
  56952 Phosphoribosyl transferase domain 0.4 2.181
  51251 5'-Nucleotidase, cytosolic Iii 0.4 6.698
  10492 Synaptotagmin binding, cytoplasmic rna interacting protein 0.4 4.116
  8347 Histone 1,H2bd 2.6 6.387
  8334 Histone 1, H2ac 5.6 1.222
  6430 Splicing factor, arginine/serine-rich 5 0.5 0
  4302 Myeloid/Lymphoid or mixed-lineage leukemia translocated to, 6 0.4 6.882
Response to stimulus     
  5806 Pentraxin-related gene, rapidly
induced by il-1 beta
14.1 1.222
  6372 Chemokine (C-X-C motif) ligand 6 5.5 1.222
  64135 Interferon induced with helicase c domain 1 0.4 6.698
  3240 Haptoglobin 4.6 0
  6648 Superoxide dismutase 2, mitochondrial 4.6 1.508
  1843 Dual specificity phosphatase 1 2.1 6.387
Cell differentiation/development     
  58189 Wap four-disulfide core domain 1 2.1 1.222
  9531 Bcl2-associated athanogene 3 3.7 0
  51454 Gulp, engulfment adaptor ptb domain containing1 0.4 2.181
  212 Aminolevulinate, delta-, synthase 2 0.4 6.698
  2012 Epithelial membrane protein 1 2.0 7.146
  79689 Steap family member 4 2.8 3.911
  9021 Suppressor of cytokine signaling 3 2.4 3.385
  5270 Serpin peptidase inhibitor, clade E, member 2 2.3 3.385
  1946 Ephrin-A5 0.4 3.911
  85444 Leucine rich repeat and coiled-coil domain containing 1 0.5 5.612
  54873 Palmdelphin 0.4 5.612
  10439 Olfactomedin 1 3.3 6.387
Carbohydrate metabolic process     
  4199 Malic enzyme 1, NADP(+)-dependent, cytosolic 0.4 3.911
  80760 Inter-alpha (Globulin) inhibitor H5 0.3 6.698
  152831 Klotho beta 2.5 0
  3101 Hexokinase 3 (White Cell) 2.9 6.387
  3099 Hexokinase 2 2.3 8.898
  1116 Chitinase 3-like 1 2.9 8.898
Protein metabolic process     
  85464 Slingshot homolog 2 2.3 1.508
  51327 Erythroid associated factor 0.06 0
  7076 Timp metallopeptidase inhibitor 1 4.4 1.222
  7053 Transglutaminase 3 6.1 1.222
  114907 F-box protein 32 0.4 6.794
  64844 Membrane-associated ring finger (C3HC4) 7 0.5 2.181
  64172 O-sialoglycoprotein endopeptidase-like 1 0.4 2.181
  55466 Dnaj (Hsp40) homolog, subfamily A, member 4 2.7 2.541
  51056 Leucine aminopeptidase 3 2.0 8.898
  2289 Fk506 binding protein 5 2.5 6.387
  26235 F-box and leucine-rich repeat protein 4 0.5 6.698
Nitrogen compound metabolic process     
  383 Arginase 0.2 2.181
  64850 Alanine-glyoxylate aminotransferase 2-like 1 0.2 6.882
  6799 Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.0 6.387
  8974 Procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha polypeptide ii 3.2 6.387
Others     
  129446 Cardiomyopathy associated 3 0.3 2.181
  128218 Transmembrane protein 125 2.0 8.898
  57763 Ankyrin repeat, family A, 2 0.4 2.181
  29970 Schwannomin interacting protein 1 0.5 6.794
  23336 Desmuslin 0.5 6.882
  590 Butyrylcholinesterase 0.5 4.116
  84649 Diacylglycerol o-acyltransferase homolog 2 3.2 1.222
  79887 Hypothetical protein Flj22662 3.5 6.387
  1. DE genes which putative functions assigned based on GO term and manual annotation. Manual annotations were listed in italics. Many genes with multiple functions were only listed in one category according to specific biology processes. "FC≥2" represents up regulation (infection/control), "FC ≤ 0.5" represents down regulation.