Skip to main content

Table 1 Different expression of genes in spleens after S. suis infection 3 days

From: Response of swine spleen to Streptococcus suis infection revealed by transcription analysis

Function classification

ENTREZ GENE_ID

Description

Fold change

Q-value (%)

Inflammatory response

    
 

929

CD14 Antigen

3.4

1.222

 

6279

S100 Calcium binding protein A8

19.3

1.508

 

6280

S100 Calcium binding protein A9

16.1

0

 

3588

Interleukin 10 receptor, beta

2.7

3.911

 

5743

Prostaglandin-Endoperoxide synthase 2

4.7

7.146

 

7057

Thrombospondin 1

2.4

6.387

 

3576

Interleukin 8

5.6

6.387

 

9547

Chemokine (C-X-C Motif) Ligand 14

2.0

8.898

 

6283

S100 Calcium binding protein A12

18.6

0

 

2908

Nuclear receptor subfamily 3, group C, member 1

0.5

6.882

 

6363

Chemokine (C-C Motif) Ligand 19

2.2

1.508

 

7097

Toll-like receptor 2

2.0

6.387

 

2920

Chemokine (C-X-C Motif) Ligand 2

7.3

3.385

 

246

Arachidonate 15-Lipoxygenase

0.2

2.181

 

7052

Transglutaminase 2

2.1

6.387

 

9332

CD163 antigen

11.7

0

 

6288

Serum amyloid A1

6.4

1.222

 

3553

Interleukin 1, beta

16.7

6.387

 

3569

Interleukin 6 (Interferon, Beta 2)

4.8

6.387

 

56729

Resistin

3.7

7.146

Response to stress

    
 

1153

Cold inducible rna binding protein

0.43

5.612

 

3320

Heat shock protein 90Kda alpha class A member 1

3.2

8.898

 

6916

Thromboxane A synthase 1

2.6

3.911

 

10963

Stress-induced-phosphoprotein 1

2.5

0

 

130872

AHA1, activator of heat shock 90Kda protein ATPase homolog 2

2.6

1.508

 

3337

Dnaj (Hsp40) homolog, subfamily B, member 1

2.8

1.222

 

871

Serpin peptidase inhibitor, clade H (Heat Shock Protein 47), member 1

2.7

1.222

 

10808

Heat shock 105Kda/110Kda protein 1

3.3

0

 

3301

Dnaj (Hsp40) homolog, subfamily A, member 1

2.4

0

 

3304

Heat Shock 70Kda Protein 1A

11.1

0

Coagulation

    
 

5328

Plasminogen activator, urokinase

2.0

6.387

 

2162

Coagulationfactor XIII, A1 polypeptide

6.8

3.385

Signal transduction

    
 

9465

A kinase anchor protein 7

0.5

6.698

 

8519

Interferon induced transmembrane protein 1

2.0

6.387

 

115265

Dna-damage-inducible transcript 4-like

0.3

2.181

 

9770

Ras association (Ralgds/Af-6) domain family 2

2.4

6.387

 

9510

Adamm etallopeptidase with thrombospondin type 1 motif, 1

2.3

0

 

1363

Carboxypeptidase E

0.44

6.698

 

54210

Triggering receptor expressed on myeloid cells 1

3.2

6.387

 

9289

G protein-coupled receptor 56

0.46

6.698

 

7043

Transforming growth factor, beta 3

2.1

4.116

Transcription

    
 

2353

V-Fos fbj murine osteosarcoma viral oncogene homolog

2.8

3.911

 

84969

Chromosome 20 open reading frame 100

0.3

2.541

 

55885

Lim domain only 3

0.3

2.181

 

3726

Jun B proto-oncogene

2.6

7.146

 

91

Activin a receptor, type ib

3.4

1.222

 

116448

Oligodendrocyte transcription factor 1

2.4

6.387

 

79365

Basic helix-loop-helix domain containing, class B, 3

0.4

2.181

 

64919

B-cell cll/lymphoma 11B

0.5

2.181

 

23635

Single-stranded dna binding protein 2

0.4

2.541

 

23414

Zinc finger protein, multitype 2

0.5

6.698

 

7552

Zinc finger protein 6 (Cmpx1)

0.5

3.385

 

6920

Transcription elongation factor A (SII), 3

2.2

6.387

 

4783

Nuclear factor, interleukin 3 regulated

2.4

3.911

 

1052

CCAAT/Enhancer binding protein (C/EBP), delta

3.1

0

Cell adhesion

    
 

6401

Selectin E

3.5

1.222

 

8174

Mucosal vascular addressin cell adhesion molecule 1

2.3

6.387

 

5067

Contactin 3

0.5

6.794

 

4867

Nephronophthisis 1 (Juvenile)

0.4

3.911

 

1462

Chondroitin sulfate proteoglycan 2 (Versican)

9.1

0

 

960

CD44 antigen

2.3

2.541

Ubiquitin cycle

    
 

115123

Membrane-associated ring finger (C3HC4) 3

4.4

1.222

 

7317

Ubiquitin-activating enzyme E1

0.4

2.181

 

11274

Ubiquitin specific peptidase 18

0.4

6.698

 

9666

Zinc finger daz interacting protein 3

0.5

6.882

Transport

    
 

6556

Solute carrier family 11, member 1

4.0

2.051

 

4057

Lactotransferrin

5.9

3.385

 

1356

Ceruloplasmin (Ferroxidase)

2.3

2.541

 

1410

Crystallin, alpha B

2.8

6.387

 

283652

Solute carrier family 24, member 5

0.4

2.181

 

54843

Synaptotagmin-like 2

0.4

6.698

 

6947

Haptocorrin

8.9

0

 

3949

Low density lipoprotein receptor

2.1

5.612

 

3043

Hemoglobin, beta

0.4

6.698

 

3042

Hemoglobin, alpha pseudogene 2

0.2

2.181

 

3040

Hemoglobin, alpha 1

0.2

2.181

 

2554

Gamma-aminobutyric acid (Gaba) a receptor, alpha 1

0.3

3.911

 

2288

Fk506 binding protein 4, 59Kda

2.2

1.222

 

6557

Solute carrier family 12, member 1

0.4

6.882

 

152789

Janus kinase and microtubule interacting protein 1

0.5

6.794

Nucleic acid metabolic process

    
 

401251

Muts homolog 5

0.5

6.698

 

56952

Phosphoribosyl transferase domain

0.4

2.181

 

51251

5'-Nucleotidase, cytosolic Iii

0.4

6.698

 

10492

Synaptotagmin binding, cytoplasmic rna interacting protein

0.4

4.116

 

8347

Histone 1,H2bd

2.6

6.387

 

8334

Histone 1, H2ac

5.6

1.222

 

6430

Splicing factor, arginine/serine-rich 5

0.5

0

 

4302

Myeloid/Lymphoid or mixed-lineage leukemia translocated to, 6

0.4

6.882

Response to stimulus

    
 

5806

Pentraxin-related gene, rapidly

induced by il-1 beta

14.1

1.222

 

6372

Chemokine (C-X-C motif) ligand 6

5.5

1.222

 

64135

Interferon induced with helicase c domain 1

0.4

6.698

 

3240

Haptoglobin

4.6

0

 

6648

Superoxide dismutase 2, mitochondrial

4.6

1.508

 

1843

Dual specificity phosphatase 1

2.1

6.387

Cell differentiation/development

    
 

58189

Wap four-disulfide core domain 1

2.1

1.222

 

9531

Bcl2-associated athanogene 3

3.7

0

 

51454

Gulp, engulfment adaptor ptb domain containing1

0.4

2.181

 

212

Aminolevulinate, delta-, synthase 2

0.4

6.698

 

2012

Epithelial membrane protein 1

2.0

7.146

 

79689

Steap family member 4

2.8

3.911

 

9021

Suppressor of cytokine signaling 3

2.4

3.385

 

5270

Serpin peptidase inhibitor, clade E, member 2

2.3

3.385

 

1946

Ephrin-A5

0.4

3.911

 

85444

Leucine rich repeat and coiled-coil domain containing 1

0.5

5.612

 

54873

Palmdelphin

0.4

5.612

 

10439

Olfactomedin 1

3.3

6.387

Carbohydrate metabolic process

    
 

4199

Malic enzyme 1, NADP(+)-dependent, cytosolic

0.4

3.911

 

80760

Inter-alpha (Globulin) inhibitor H5

0.3

6.698

 

152831

Klotho beta

2.5

0

 

3101

Hexokinase 3 (White Cell)

2.9

6.387

 

3099

Hexokinase 2

2.3

8.898

 

1116

Chitinase 3-like 1

2.9

8.898

Protein metabolic process

    
 

85464

Slingshot homolog 2

2.3

1.508

 

51327

Erythroid associated factor

0.06

0

 

7076

Timp metallopeptidase inhibitor 1

4.4

1.222

 

7053

Transglutaminase 3

6.1

1.222

 

114907

F-box protein 32

0.4

6.794

 

64844

Membrane-associated ring finger (C3HC4) 7

0.5

2.181

 

64172

O-sialoglycoprotein endopeptidase-like 1

0.4

2.181

 

55466

Dnaj (Hsp40) homolog, subfamily A, member 4

2.7

2.541

 

51056

Leucine aminopeptidase 3

2.0

8.898

 

2289

Fk506 binding protein 5

2.5

6.387

 

26235

F-box and leucine-rich repeat protein 4

0.5

6.698

Nitrogen compound metabolic process

    
 

383

Arginase

0.2

2.181

 

64850

Alanine-glyoxylate aminotransferase 2-like 1

0.2

6.882

 

6799

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2

2.0

6.387

 

8974

Procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha polypeptide ii

3.2

6.387

Others

    
 

129446

Cardiomyopathy associated 3

0.3

2.181

 

128218

Transmembrane protein 125

2.0

8.898

 

57763

Ankyrin repeat, family A, 2

0.4

2.181

 

29970

Schwannomin interacting protein 1

0.5

6.794

 

23336

Desmuslin

0.5

6.882

 

590

Butyrylcholinesterase

0.5

4.116

 

84649

Diacylglycerol o-acyltransferase homolog 2

3.2

1.222

 

79887

Hypothetical protein Flj22662

3.5

6.387

  1. DE genes which putative functions assigned based on GO term and manual annotation. Manual annotations were listed in italics. Many genes with multiple functions were only listed in one category according to specific biology processes. "FC≥2" represents up regulation (infection/control), "FC ≤ 0.5" represents down regulation.