Figure 3

Comparison of hepatic gene expression signatures for TCDD, PCB126 and PCB153. Venn diagram depicting the number of genes shared by the hepatic gene expressions signatures in female Sprague-Dawley rats following subchronic and chronic exposure to TCDD (100 ng/kg/day), PCB126 (1000 ng/kg/day) or PCB153 (1000 μg/kg/day). In parenthesis is the total number of genes differentially expressed for each compound following both 13 and 52 weeks of exposure. The 41 genes shared in common by exposures to TCDD and PCB126 represent genomic biomarkers of subchronic and chronic exposure to AhR ligands or the time independent gene expression signature of the AhR ligands.