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Table 5 Relative fold change in genes differentially expressed in human intrahepatic cholangiocarcinoma (ICC) and the hepatic gene expression profiles of rats exposed to TCDD, PCB126, and PCB153 p.o. for 52 weeks

From: Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

Transcript ID Rat Ortholog Rat Gene Name Human Ortholog ICC[25] ICC[24] TCDD 100 ng/kg/day PCB126 1000 ng/kg/day PCB153 1000 μg/kg/day
NM_144755 Trib3 Tribbles homolog 3 (Drosophila) TRIB3 18 N/C 16 13 N/C
NM_016988 Acp2 Acid phosphatase 2, lysosomal ACP2 2 N/C 3 2 N/C
NM_021261 Tmsb10 Thymosin, beta 10 TMSB10 2 N/C 2 N/C N/C
NM_017059 Bax Bcl2-associated X protein BAX 4 N/C 2 N/C N/C
NM_019287 Apob Apolipoprotein B APOB N/C -3 -9 N/C N/C
NM_019185 Gata6 GATA binding protein 6 GATA6 -4 -5 -3 -4 N/C
NM_013219 Cadps Ca2+-dependent secretion activator CADPS N/C -16 -3 -3 N/C
NM_012886 Timp3 Tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) TIMP3 -11 -3 -2 N/C N/C
NM_017158 Cyp2c7 Cytochrome P450, family 2, subfamily c, polypeptide 7 CYP2C9 N/C -3 -2 -2 N/C
NM_134432 Agt Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) AGT N/C -6 -2 N/C N/C
NM_053598 Nudt4 Nudix (nucleoside diphosphate linked moiety X)-type motif 4 NUDT4 -3 N/C -2 N/C N/C
NM_013029 St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 ST8SIA3 -2 N/C -2 N/C N/C
NM_012596 Lepr Leptin receptor LEPR -8 N/C -2 N/C N/C
NM_022501 Crip2 Cysteine-rich protein 2 CRIP -9 N/C -3 -3 N/C
NM_031132 Tgfbr2 Transforming growth factor, beta receptor II TGFBR2 -4 N/C -3 N/C N/C
NM_001025271 Sfpq Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) SFPQ -5 N/C -3 N/C N/C
NM_001007235 Itpr1 Inositol 1,4,5-triphosphate receptor 1 ITPR1 -3 N/C -3 -3 N/C
NM_053328 Bhlhb2 Basic helix-loop-helix domain containing, class B2 BHLHB2 -4 N/C -4 N/C N/C
NM_001013137 Cxcl14 Chemokine (C-X-C motif) ligand 14 CXCL14 -11 N/C -4 -10 N/C
NM_031561 Cd36 Cd36 antigen CD36 -5 N/C -6 -4 N/C
NM_031135 Klf10 Kruppel-like factor 10 KLF10 -4 N/C -10 N/C N/C
NM_022251 Enpep Glutamyl aminopeptidase ENPEP -2 N/C -12 -5 N/C
NM_031648 Fxyd1 FXYD domain-containing ion transport regulator 1 FXYD1 -14 N/C N/C -2 N/C
NM_053698 Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 CITED2 -4 N/C N/C -4 N/C
  1. N/C indicates no change in gene expression for that treatment.