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Table 6 Relative fold change in genes differentially expressed in human hepatocellular adenoma (HCA), rat HCA and the hepatic gene expression profiles of rats exposed to TCDD, PCB126, and PCB153 p.o. for 52 weeks

From: Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

Transcript ID Gene Symbol Rat Gene Name Human Ortholog HCA[23] HCA[22] TCDD 100 ng/kg/day PCB126 1000 ng/kg/day PCB153 1000 μg/kg/day
NM_053401 Ngfrap1 Nerve growth factor receptor (TNFRSF16) associated protein 1 NGFRAP1 N/C 13 8 6 N/C
NM_012752 Cd24 CD24 antigen CD24 10 N/C 7 4 N/C
NM_017127 Chka Choline kinase alpha CHKA 2 N/C 5 6 N/C
NM_057104 Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase 2 ENPP2 4 N/C 4 5 N/C
NM_017166 Stmn1 Stathmin 1 STMN1 2 N/C 4 N/C 2
NM_145878 Fabp5 Fatty acid binding protein 5, epidermal FABP5 2 N/C 4 3 N/C
NM_022298 Tuba1 Tubulin, alpha 1 TUBA4A N/C 11 3 N/C N/C
NM_053515 Slc25a4 Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 SLC25A4 N/C 8 3 N/C N/C
NM_012862 Mgp Matrix Gla protein MGP 4 N/C 3 3 N/C
NM_012946 Sparcl1 SPARC-like 1 (mast9, hevin) SPARCL1 3 N/C 2 2 N/C
NM_030987 Gnb1 Guanine nucleotide binding protein, beta 1 GNB1 2 N/C N/C 3 N/C
NM_031795 Ugcg UDP-glucose ceramide glucosyltransferase UGCG 2 N/C N/C N/C 2
NM_023103 Mug1 Murinoglobulin 1 homolog (mouse) none N/C -5 -2 N/C N/C
NM_134432 Agt Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) AGT N/C -5 -2 N/C N/C
NM_012899 Alad Aminolevulinate, delta-, dehydratase ALAD -2 N/C -2 -3 N/C
NM_053770 Argbp2 Arg/Abl-interacting protein ArgBP2 ARGBP2 -3 N/C -2 N/C N/C
NM_022508 Mthfd1 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase MTHFD1 -5 N/C -2 N/C N/C
NM_012716 Slc16a1 Solute carrier family 16 (monocarboxylic acid transporters), member 1 SLC16A1 -3 N/C -2 N/C N/C
NM_013177 Got2 Glutamate oxaloacetate transaminase 2, mitochondrial GOT2 -2 N/C N/C N/C -2
NM_012737 Apoa4 Apolipoprotein A-IV APOA4 N/C -9 -3 -4 N/C
NM_053923 Pik3c2g Phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide PIK3C2G -3 N/C -3 -3 N/C
NM_024484 Alas1 Aminolevulinic acid synthase 1 ALAS1 -3 N/C -3 -3 2
NM_019185 Gata6 GATA binding protein 6 GATA6 -3 N/C -3 -4 N/C
NM_053328 Bhlhb2 Basic helix-loop-helix domain containing, class B2 BHLHB2 -2 N/C -4 N/C N/C
XM_001076124///XM_001076147///XM_001076171///XM_341825 Prodh2 Proline dehydrogenase (oxidase) 2 PRODH2 -3 N/C N/C -3 N/C
NM_147206 Cyp3a13 Cytochrome P450, family 3, subfamily a, polypeptide 13 CYP3A4 N/C -9 -606 -610 N/C
  1. N/C indicates no change in gene expression for that treatment.