Skip to main content

Table 1 P-DUDES gene expression in cancer and cancer models

From: A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins

gene direction tissue mechanism proposed reference
CCDC80 DOWN rat epithelial cells neoplastically transformed by β-catenin.   [9]
CCDC80 DOWN thyroid neoplastic cell lines and tissues   [14]
CCDC80 DOWN colon and pancreatic cancer cells. mediates growth inhibition [9]
SRPX DOWN highly malignant human pulmonary neuroendocrine tumors.   [10]
SRPX DOWN prostate carcinomas.   [89]
SRPX DOWN colorectal neoplasms.   [90]
SRPX DOWN lung adenocarcinomas.   [91]
SRPX DOWN colon adenocarcinomas.   [92]
SRPX DOWN endothelial cells, myeloma   [93]
SRPX DOWN stromal fibroblast cells from liver metastases of colorectal cancer   [94]
SRPX NA SRPX knock-out mouse embryonic fibroblasts involvement in the maturation process of autophagy [13]
SRPX NA malignant tumors including lymphomas, lung adenocarcinomas and hepatomas Tumors appear in SRPX-knock out mice [11]
SRPX NA human cancer cell lines. apoptosis induction in human cancer cell lines; both the P-DUDES and the sushi regions necessary [12]
SRPX2 NA endothelial cells mediator of angiogenesis [20]
SRPX2 NA   ligand for uPAR [19]
SRPX2 UP gastric cancer enhancing cellular migration and adhesion through FAK signaling [16, 17]
SRPX2 UP pro-B leukemia cells   [5]