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Table 3 Down-regulation of genes in iBMDCs treated with [BF/S+L/Ep] for (A) 4 h or (B) 12 h compared to DMSO alone

From: Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses

 

Gene Title

Accession Number

Expression Ratioa(+)/(-)

At 4 h:

   

   Cluster 1

Adhesion molecules, Cytoskeleton, Cell movement

  

   Cnn3

calponin 3, acidic

NM_028044

0.13

   Cdh10

cadherin 10

Q3UUB3

0.27

   Itga6

Integrin alpha 6

NM_008397

0.50

   Cluster 2

Cell cycle, DNA repair, Apoptosis

  

   Sycp1

synaptonemal complex protein 1

NM_011516

0.25

   Cluster 3

Enzyme, Kinase

  

   Atad1

ATPase family, AAA domain containing 1

NM_026487

0.48

   St8sia6

ST8 alpha-N-acetyl-neuraminide alpha-2,8-

sialyltransferase 6

NM_145838

0.45

   Prkce

Protein kinase C, epsilon

NM_011104

0.47

   Cluster 4

DNA binding protein, Transcription factor

  

   Shprh

SNF2 histone linker PHD RING helicase

NM_172937

0.27

   Zfp39

zinc finger protein 39

NM_011758

0.31

   Cluster 5

Miscellaneous

  

   Cep110

centrosomal protein 110

XM_981952

0.46

At 12 h:

   

   Cluster 1

Adhesion molecules, cytoskeleton; cell movement

  

   Cdh1

Cadherin 1

NM_009864

0.30

   Gja1

gap junction membrane channel protein alpha 1

NM_010288

0.48

   Cluster 2

Signal transmission, Transporter

  

   Rab17

RAB17, member RAS oncogene family

NM_008998

0.42

   Oscar

osteoclast associated receptor

NM_175632

0.44

   Kcne3

Voltage-gated potassium channel, Isk-related subfamily, gene 3

NM_020574

0.49

   Sla

src-like adaptor

NM_009192

0.50

   Cluster 3

Enzyme, Kinase

  

   Setd4

SET domain containing 4

NM_145482

0.32

   Ndufb2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2

NM_026612

0.39

   Acss1

acyl-CoA synthetase short-chain family member 1

NM_080575

0.40

   Cluster 4

DNA binding protein, Transcription factor

  

   Sox6

SRY-box containing gene 6

NM_011445

0.06

   Dmc1h

disrupted meiotic cDNA 1 homolog

NM_010059

0.17

   Nfxl1

nuclear transcription factor, X-box binding-like 1

Q3ULV1

0.36

   Huwe1

HECT, UBA and WWE domain containing 1

NM_021523

0.41

   Cluster 5

Protein metastasis

  

   Fbxo36

F-box only protein 36

NM_025386

0.46

   Cluster 6

RNA binding protein, Translation factor

  

   Rbm14

RNA binding motif protein 14

NM_019869

0.50

   Cluster 7

Miscellaneous

  

   Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

NM_028561

0.19

   Ccdc21

coiled-coil domain containing 21

NM_144527

0.47

   Mgl1

macrophage galactose N-acetyl-galactosamine specific lectin 1

NM_010796

0.48

  1. a Expression ratio is defined as relative difference in expression with (+) compared to without (-) treatment with [BF/S+L/Ep] plant extract; (-) is DMSO vehicle control.
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BMC Genomics

ISSN: 1471-2164

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