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Table 3 Top 10 fold-changing genes from each temporal cluster following infestation with P. ovis

From: Transcriptomic analysis of the temporal host response to skin infestation with the ectoparasitic mite Psoroptes ovis

Cluster ID Gene Symbol Gene Description Fold Change*
Cluster 1 TMEM123 Transmembrane protein 123 19.3
  CD83 CD83 molecule 9.1
  ATF3 Activating transcription factor 3 7.5
  CYR61 Cysteine-rich, angiogenic inducer, 61 5.4
  BTG2 BTG family, member 2 5.3
  EGR1 early growth response 1 4.5
  CYR61 (2×) cysteine-rich, angiogenic inducer, 61 4.5
  GPR171 G protein-coupled receptor 171 4.4
  GADD45B growth arrest and DNA-damage-inducible, beta 4.1
Cluster 2 IL6 Interleukin-6 771.7
  CCL2 Chemokine (C-C motif) ligand 2 35.7
  CXCL2 Chemokine (C-X-C motif) ligand 2 22.7
  Unknown N/A 19.1
  SELP (2×) Selectin P (granule membrane protein 140 kDa, antigen CD62) 17.2 to 18.1
  SOCS3 Suppressor of cytokine signalling 3 18.0
  CSF3 colony stimulating factor 3 (granulocyte) 17.6
  PDE4B phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) 17.1
  TNFAIP6 tumor necrosis factor, alpha-induced protein 6 16.7
Cluster 3 PTX3 (2×) Pentraxin 3 225.6 to 317.2
  MMP1 (2×) Matrix metallopeptidase 1 (interstitial collagenase) 237.1 to 302.8
  CXCL5 Chemokine (C-X-C motif) ligand 5 218.0
  SDS Serine dehydratase 134.3
  MT1E Metallothionein 1E 76.9
  PLEK pleckstrin 48.8
  MS4A8B membrane-spanning 4-domains, subfamily A, member 8B 45.2
  SOD2 superoxide dismutase 2, mitochondrial 31.5
Cluster 4 IL8 (2×) Interleukin-8 291.7 to 617.4
  SPRR2A Small proline-rich protein 2A 324.5
  CSN2 Casein beta 174.7
  SPRR2E (2×) small proline-rich protein 2E 109.7 to 163.2
  LTF Lactotransferrin 121.9
  S100A9 S100 calcium binding protein A9 90.9
  ASGR2 asialoglycoprotein receptor 2 66.4
  S100A12 S100 calcium binding protein A12 66.3
Cluster 5 # APOBEC2 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -4.6
  Unknown N/A -2.1
  ZACN Zinc activated ligand-gated ion channel -2.0
  HSPA8 Heat shock 70 kDa protein 8 -1.7
  ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 -1.7
  FGL2 Fibrinogen-like 2 -1.6
Cluster 6 SFRP4 Secreted frizzled-related protein 4 -5.0
  TXNIP (3×) Thioredoxin interacting protein -3.4 to -3.9
  Unknown N/A -2.8
  SERPINF1 Serpin peptidase inhibitor, clade F, member 1 -2.7
  FZD2 (2×) Frizzled homolog 2 -2.6 to -2.7
  C3 Complement component 3 -2.4
  FCGBP Fc fragment of IgG binding protein -2.3
Cluster 7 SDPR Serum deprivation response -19.7
  NOSTRIN nitric oxide synthase trafficker -6.6
  FAM13C Family with sequence similarity 13, member C -5.8
  CDKN1C Cyclin-dependent kinase inhibitor 1C (p57, Kip2) -5.8
  Unknown N/A -5.6
  LIX1L Lix1 homolog (mouse)-like -5.5
  SCARA5 Scavenger receptor class A, member 5 (putative) -5.3
  COL3A1 collagen, type III, alpha 1 -4.9 to -5.1
Cluster 8 CYP2F1 Cytochrome P450, family 2, subfamily F, polypeptide 1 -29.2
  CAP2 CAP, adenylate cyclase-associated protein, 2 -28.5
  LOR Loricrin -26.3
  IGFBP1 Insulin-like growth factor binding protein 1 -23.4
  STMN2 Stathmin-like 2 -12.9
  GFRA2 GDNF family receptor alpha 2 -11.5
  CYP2B Cytochrome P450, family 2, subfamily B -9.3
  FLG Filaggrin -8.6
  KRT1 Keratin 1 -7.0
  FMO3 Flavin containing monooxygenase 3 -6.4
  1. Key - *Fold change calculated relative to baseline samples (Time = 0), range given where 2 or more probes for a gene are present. #Cluster 5 contained only 6 genes