Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset

Table 1 Regional spousal identity.

Similarity only	SNPs	Fisher meta	Background	P value
		Value	Mean Fisher
			Value
HLA region	458	7.7 * 10^-10	0.15	0.013
HLA class I region	280	1.0 * 10^-8	0.043	0.029
HLA class II region	90	0.82	0.35	0.83
HLA class III region	88	6.4 * 10^-6	0.36	0.09
OR13 region chr. 9	25	3.8 * 10^-43	0.48	8.8 * 10^-5
Dissimilarity only	SNPs	Fisher meta	Background	P value
		Value	Mean Fisher
			Value
HLA region	246	0.11	0.61	0.20
HLA class I region	140	0.43	0.56	0.39
HLA class II region	63	0.063	0.59	0.12
HLA class III region	43	0.24	0.60	0.27
OR13 region chr. 9	60	0.24	0.41	0.48
Combined	SNPs	Fisher meta	Background	P value
Similarity and Dissimilarity		Value	Mean Fisher
			Value
HLA region	704	7.5 * 10^-9	0.51	0.0025
HLA class I region	420	7.3 * 10^-7	0.033	0.23
HLA class II region	153	0.38	0.49	0.44
HLA class III region	131	2.6 * 10^-5	0.53	0.047
OR13 region chr. 9	85	7.7 * 10^-29	0.52	0.00056
Position	Recombination rate cM/Mb		Start	End
HLA region	1.57		29,700,000	33,300,000
HLA class I region	1.38		29,700,000	31,500,000
HLA class II region	2.43		32,500,000	33,300,000
HLA class III region	1.12		31,500,000	32,500,000
OR13 region chr. 9	0.69		104,000,000	104,500,000

The MHC region as a whole shows similarity between couples. When broken down into classes, class I shows significant similarity between couples. Of the three MHC classes, class II shows the most dissimilarity between couples, albeit not statistically significant. HLA-B and HLA-DRA denote the boundaries between the three MHC classes. UCSC Build 35 coordinates are shown.

ISSN: 1471-2164