Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset

Table 2 Excessive homozygosity in the general population.

Observed (expected)	Excessive heterozygosity	Excessive homozygosity
Dissimilar among couples	16 (7.97)	20 (28.03)
Similar among couples	13 (21.03)	82 (73.97)

SNPs that are dissimilar among couples in the IMSGC dataset tend to show excessive heterozygosity in the HapMap CEU samples, while markers that are similar among IMSGC couples show excessive homozygosity in the HapMap samples (chi-square p < 0.004, expected values shown in parentheses). In all, 131 SNPs showed significant similarity or dissimilarity among IMSGC couples (p < 0.024) and significant deviation from Hardy-Weinberg equilibrium in the independent HapMap CEU dataset (p < 0.024).

ISSN: 1471-2164