Imprinted genes show unique patterns of sequence conservation

BMC Genomics

Table 1 General sequence properties of human genes

	imprinted	maternally expressed	paternally expressed	autosomal
G+C content of genes	46.56%	46.91%	45.98%	45.47%
CpG_obs/CpG_exp of genes	0.305	0.305	0.315	0.280
gene length (bp)	29641	46976	26829	22422
intron length (bp)	1637*	1652	1633	1549
length of intergenic regions (bp)	50879*	49483	55322	26410
coverage of introns with purely intronic PCSs	0.74%	0.69%	1.09%	0.45%
purely intronic PCSs per 10 kb of intron per gene	1.72	1.35	2.04	1.06
coverage of intergenic regions with PCSs	0.66%	0.74%	0.64%	1.11%
intergenic PCSs per 10 kb per gene	1.29	1.41	1.29	2.17

* p < 0.01 (Wilcoxon test for comparison with autosomal genes)
Gene length: length of transcribed DNA sequence from most upstream transcriptional start site to most downstream transcriptional termination site; intergenic region: For this, the intergenic segments between any two genes were cut into two halves. Each of them was assigned to the closest gene. As intergenic region of a gene we then added the lengths of the halved upstream intergenic segment and of the halved downstream intergenic segment. Since the features show a highly skewed distribution, medians are given instead of averages and standard deviations.

ISSN: 1471-2164