up-regulated gene sets | description | WC 3 h | WCCo 3 h | CoCl2 3 h | WC 3 d | WCCo 3 d | CoCl2 3 d |
---|---|---|---|---|---|---|---|
hypoxia related gene sets | Â | Â | Â | Â | Â | Â | Â |
HIF1_TARGETS | Hif-1 (hypoxia-inducible factor 1) transcriptional targets | Â | 0.17 | Â | Â | 0.01 | Â |
HIFPATHWAY | BIOCARTA: Under normal conditions, HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hypoxic response elements (HREs) | Â | Â | Â | Â | 0.02 | 0.20 |
HYPOXIA_FIBRO_UP | Up-regulated by hypoxia in normal fibroblasts from both young and old donors | Â | 0.20 | Â | 0.65 | 0.05 | Â |
HYPOXIA_NORMAL_UP | Up-regulated by hypoxia in normal, RPTEC renal cells | Â | 0.50 | Â | Â | 0.02 | Â |
HYPOXIA_REG_UP | Up-regulated by hypoxia in renal cells, and down-regulated with reoxygenation | Â | 0.05 | Â | Â | 0.01 | 0.03 |
HYPOXIA_REVIEW | Genes known to be induced by hypoxia | Â | 0.22 | Â | 0.75 | 0.00 | Â |
MANALO_HYPOXIA_UP | Genes up-regulated in human pulmonary endothelial cells under hypoxic conditions or after exposure to AdCA5, an adenovirus carrying constitutively active hypoxia-inducible factor 1 (HIF-1alpha) | Â | 0.24 | Â | Â | 0.01 | 0.21 |
MENSE_HYPOXIA_UP | List of Hypoxia-induced genes found in both Astrocytes and HeLa Cell | Â | 0.00 | Â | Â | 0.02 | 0.13 |
RESPONSE_TO_HYPOXIA | GO:0001666. Change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension | Â | Â | Â | Â | 0.12 | 0.08 |
carbohydrate metabolism | Â | Â | Â | Â | Â | Â | Â |
POLYSACCHARIDE_METABOLIC_PROCESS | GO:0005976. Chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages | Â | Â | Â | Â | 0.06 | Â |
FRUCTOSE_AND_MANNOSE_METABOLISM | Genes involved in fructose and mannose metabolism | Â | 0.21 | Â | Â | 0.02 | Â |
HSA00010_GLYCOLYSIS_AND_ GLUCONEOGENESIS | KEGG: Genes involved in glycolysis and gluconeogenesis | Â | Â | Â | Â | 0.00 | 0.14 |
GLYCOGEN_METABOLISM | Genes involved in glycogen metabolism | Â | Â | Â | Â | 0.04 | Â |
GALACTOSE_METABOLISM | Genes involved in galactose metabolism | Â | Â | Â | Â | 0.04 | Â |
PENTOSE_PHOSPHATE_PATHWAY | Genes involved in pentose phosphate pathway | Â | Â | Â | 0.61 | 0.14 | Â |
STARCH_AND_SUCROSE_ METABOLISM | Genes involved in starch and sucrose metabolism | Â | Â | Â | Â | 0.01 | 0.50 |
endocrine metabolism | Â | Â | Â | Â | Â | Â | Â |
GN_CAMP_GRANULOSA_UP | Up-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP- stimulator forskolin | Â | Â | Â | Â | 0.01 | 0.17 |
LH_GRANULOSA_UP | Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) | Â | Â | Â | Â | 0.01 | Â |
FSH_GRANULOSA_UP | Up-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) | Â | Â | Â | Â | 0.01 | Â |
BREAST_CANCER_ESTROGEN_SIGNALING | Genes preferentially expressed in breast cancers, especially those involved in estrogen-receptor- dependent signal transduction | Â | Â | Â | Â | 0.05 | Â |
PROSTAGLANDIN_SYNTHESIS_ REGULATION | WIKIPATHWAYS: Prostaglandin Synthesis and Regulation | Â | 0.09 | Â | Â | Â | Â |
HSA04150_MTOR_SIGNALING_ PATHWAY | KEGG: Genes involved in mTOR signalling pathway | Â | 0.19 | Â | Â | Â | Â |
cell adhesion, structure, cytoskeleton | Â | Â | Â | Â | Â | Â | Â |
HSA04510_FOCAL_ADHESION | KEGG: Genes involved in focal adhesion | Â | Â | Â | Â | 0.07 | 0.46 |
ACTIN_CYTOSKELETON | GO:0015629. Part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins | Â | Â | Â | Â | 0.04 | Â |
ACTIN_BINDING | GO:0003779. Interacting selectively with monomeric or multimeric forms of actin, including actin Filaments | Â | Â | Â | Â | 0.06 | Â |
CYTOSKELETON_DEPENDENT_ INTRACELLULAR_TRANSPORT | GO:0030705. The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell | Â | Â | Â | Â | 0.07 | Â |
ANATOMICAL_STRUCTURE_FORMATION | GO:0048646. Process pertaining to the initial formation of an anatomical structure from unspecified parts | Â | Â | Â | Â | 0.04 | Â |
VASCULATURE_DEVELOPMENT | GO:0001944. Process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure | Â | Â | Â | Â | 0.04 | Â |
ANGIOGENESIS | GO:0001525. Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels | Â | Â | Â | Â | 0.05 | Â |
HSA04512_ECM_ RECEPTOR_INTERACTION | KEGG: Genes involved in ECM-receptor interaction | Â | Â | Â | Â | 0.06 | 0.29 |
miscellaneous | Â | Â | Â | Â | Â | Â | Â |
G13_SIGNALING_PATHWAY | G13 signaling pathway | Â | Â | Â | Â | 0.10 | 0.51 |
NUCLEOTIDE_BIOSYNTHETIC_PROCESS | GO:0009165. Chemical reactions and pathways resulting in the formation of nucleotides | Â | Â | Â | Â | 0.09 | Â |
CARBON_CARBON_LYASE_ACTIVITY | GO:0016830. Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond | Â | Â | Â | Â | 0.10 | Â |
ALKPATHWAY | Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development | Â | Â | Â | Â | Â | 0.29 |
CARDIACEGFPATHWAY | BIOCARTA: Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway | Â | 0.21 | Â | Â | 0.01 | Â |
WNT_SIGNALING | Wnt signaling genes | Â | Â | Â | Â | 0.01 | Â |
HSA05211_RENAL_CELL_CARCINOMA | Genes involved in renal cell carcinoma | Â | Â | Â | Â | 0.07 | Â |
NKTPATHWAY | BIOCARTA: T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response | Â | Â | Â | Â | Â | 0.29 |
BIOGENIC_AMINE_SYNTHESIS | WIKIPATHWAYS: Genes involved in synthesis of biogenic amines | Â | 0.23 | Â | Â | Â | Â |
HSA00591_LINOLEIC_ACID_METABOLISM | Genes involved in linoleic acid metabolism | Â | 0.22 | Â | Â | Â | Â |
HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION | KEGG: Genes involved in gamma-hexachlorocyclohexane degradation | Â | 0.17 | Â | Â | Â | Â |
down-regulated gene sets | description | WC 3 h | WCCo 3 h | CoCl2 3 h | WC 3 d | WCCo 3 d | CoCl2 3 d |
RNA metabolism and processing | Â | Â | Â | Â | Â | Â | Â |
MRNA_METABOLIC_PROCESS | GO:0016071. Chemical reactions and pathways involving mRNA | Â | 0.23 | Â | Â | Â | Â |
RIBONUCLEOPROTEIN_COMPLEX_ | GO:0022613. The cellular process by which a complex containing RNA and proteins, is synthesized, | Â | 0.25 | Â | Â | Â | Â |
BIOGENESIS_AND_ASSEMBLY | aggregates, and bonds together | Â | Â | Â | Â | Â | Â |
RNA_PROCESSING | GO:0006396. Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules | Â | 0.20 | Â | Â | Â | Â |
RNA_SPLICING__VIA_TRANSESTERIFICATION_ REACTIONS | GO:0000375. Splicing of RNA via a series of two transesterification reactions | Â | 0.20 | Â | Â | Â | Â |
SEQUENCE_SPECIFIC_ DNA_BINDING | GO:0043565. Interacting selectively with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding | Â | 0.33 | Â | Â | Â | Â |
TRNA_METABOLIC_PROCESS | GO:0006399. Chemical reactions and pathways involving tRNA | Â | 0.27 | Â | Â | Â | Â |
nucleus and the nuclear membrane related gene sets | Â | Â | Â | Â | Â | Â | Â |
PORE_COMPLEX | GO:0046930. Any small opening in a membrane that allows the passage of gases and/or liquids. | Â | 0.28 | Â | Â | Â | Â |
NUCLEAR_PORE | GO:0005643. Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined | Â | 0.19 | Â | Â | Â | Â |
NUCLEAR_LUMEN | GO:0031981. The volume enclosed by the nuclear inner membrane | Â | 0.31 | Â | Â | Â | Â |
NUCLEAR_MEMBRANE | GO:0031965. Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space | Â | 0.31 | Â | Â | Â | Â |
enzyme and receptor activity | Â | Â | Â | Â | Â | Â | Â |
UBIQUITIN_PROTEIN_ LIGASE_ACTIVITY | GO:0004842. Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine | Â | 0.32 | Â | Â | Â | Â |
SMALL_PROTEIN_CONJUGATING_ ENZYME_ACTIVITY | GO:0008639. Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin-like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase | Â | 0.21 | Â | Â | Â | Â |
CASPASEPATHWAY | BIOCARTA: Caspases are cysteine proteases active in apoptosis | Â | Â | Â | 0.30 | Â | Â |