Figure 1

Clustered GO terms and KEGG pathways significantly enriched for differentially expressed genes in five comparisons. In total, 318 GO and KEGG pathways with FDR < 0.01 were included in the figure. Each column represents the experimental condition as indicated on the map. Each row represents one GO term/KEGG pathway. These are summarized for each main cluster. Baseline male vs. female (M/F): GO/KEGG significantly enriched for differentially expressed genes in male vs. female muscle in the resting state: Red color indicates strength of enrichment with higher expressed genes in males (or lower expression in females); green indicates enrichment with lower expressed genes in males (or higher expression in females). Male 4 h, Male 24 h, Female 4 h and Female 24 h: GO/KEGG significantly enriched for RE-induced up-and down-regulated genes in male muscle at 4 h (Male 4 h) and 24 h post exercise (Male 24 h), in female muscle at 4 h (female 4 h) and 24 h post exercise (Female 24 h): Red color indicates strength of RE-induced up-regulation and green indicates down-regulation. The -log10(p-value) of enrichment was used as the value for clustering.