Figure 1

Overview of genome-wide profiling of histone methylation, DNA methylation and gene expression of prostate cells. (A) Flowchart of ChIP-chip, MeDIP-chip and gene expression microarray profiling of EP156T, EPT1 and EPT2 cells. (B) Summary of detected probes and genes that were modified by H3K4me3, H3K27me3 and DNAMe in EP156T, EPT1 and EPT2 cells. Around 20%, 10% and 3% of probes detected significant H3K4me3, H3K27me3 and DNAMe modification, respectively, in the three cell lines. (C) Gene distribution according to the expression levels in EP156T cells. Genes with expression level above 7.5 were considered as expressed genes, genes with expression level below 7.5 were considered as silenced genes.