Figure 3

Substitutions at synonymous sites categorized by specific base-pair replacements, showing a similar preference for G:C to A:T transversions among isolates of the R86 cluster and R220 cluster as for other mycobacterial strains such as CDC1551 and F11. All substitutions were based on comparison to H37Rv. The total number of synonymous SNPs analyzed was 112, 126, and 537 for R86, R220, and CDC1551/F11, respectively.