Figure 4

Localization of up-regulated phosphoproteins and kinases predicted to be responsible for elevated phosphorylation levels. Panel (A) Bar chart indicating localization of proteins displaying significantly increased phosphorylation levels. The % of proteins being localized in the respective categories was calculated for up-regulated proteins and normalized to the localization distribution determined for all detected proteins. The yellow color highlights proteins of the nucleus and nucleolus. Panel (B) Bar chart indicating kinases predicted to be responsible for the observed elevated phosphorylation sites. The % of phospho-sites being targeted by the respective kinases was calculated for up regulated sites and normalized to the background of detected unchanged phospho-sites, revealing the predominant role of SNF1 in the observed increased phosphorylation in the nat3Δ strain.