B6 (n) | F1 (n) | TH (n) | F2 (n) (lowest, highest) | 16 F2 mice chosen for microarray Lower (n = 8); Upper (n = 8) | |
---|---|---|---|---|---|
Triglyceride (mg/dl) | |||||
8 wk | 63 ± 12 (9)a | 153 ± 12 (15)b | 438 ± 41 (7)c | 168 ± 3 (368) (60, 472) | 130 ± 14; 207 ± 22 (P = 0.009) |
12 wk | 68 ± 8 (14)a | 186 ± 11 (19)b | 237 ± 53 (9)b | 166 ± 3 (382) (44, 357) | 135 ± 14; 230 ± 22 (P = 0.003) |
16 wk | 63 ± 3 (18)a | 168 ± 8 (19)b | 438 ± 39 (16)c | 167 ± 4 (384) (20, 486) | 120 ± 15; 191 ± 27 (P = 0.038) |
20 wk | 71 ± 7 (18)a | 180 ± 20 (19)b | 367 ± 32 (16)c | 181 ± 4 (377) (56, 479) | 126 ± 17; 336 ± 24 (P < 0.0001) |
24 wk | 60 ± 6 (18)a | 221 ± 19 (19)b | 368 ± 33 (16)c | 181 ± 4 (375) (40, 436) | 81 ± 7; 331 ± 17 (P < 0.0001) |
Cholesterol (mmol/l) | |||||
8 wk | 2.9 ± 0.2 (9)a | 2.3 ± 0.1 (15)b | 4.0 ± 0.1 (7)c | 2.9 ± 0.1 (365) (0.7, 7.6) | 2.2 ± 0.2; 2.9 ± 0.4 (P = 0.09) |
12 wk | 2.6 ± 0.2 (14)a | 3.1 ± 0.2 (19)b | 2.9 ± 0.1 (9)b | 3.1 ± 0.1 (378) (0.4, 8.5) | 2.5 ± 0.3; 3.1 ± 0.5 (P = 0.36) |
16 wk | 3.0 ± 0.3 (19)a | 2.6 ± 0.1 (19)a | 3.6 ± 0.3 (16)b | 3.0 ± 0.1 (384) (1.0, 6.8) | 2.5 ± 0.3; 3.6 ± 0.4 (P = 0.04) |
20 wk | 2.1 ± 0.1 (18)a | 3.5 ± 0.3 (19)b | 4.7 ± 0.3 (16)c | 3.3 ± 0.1 (377) (1.1, 6.8) | 2.7 ± 0.3; 3.6 ± 0.2 (P = 0.03) |
24 wk | 1.9 ± 0.1 (18)a | 3.6 ± 0.1 (19)b | 4.0 ± 0.4 (16)b | 3.3 ± 0.1 (375) (1.3, 8.1) | 2.8 ± 0.2; 3.1 ± 0.5 (P = 0.58) |
Glucose (mg/dl) | |||||
8 wk | 175 ± 10 (9)a | 175 ± 11 (15)a | 292 ± 48 (7)b | 176 ± 2 (368) (98, 353) | 163 ± 11; 183 ± 9 (P = 0.20) |
12 wk | 132 ± 6 (14)a | 147 ± 9 (19)a | 252 ± 40 (9)b | 166 ± 2 (382) (45, 473) | 145 ± 8; 168 ± 11 (P = 0.10) |
16 wk | 181 ± 14 (19)a | 166 ± 4 (19)a | 460 ± 38 (16)b | 169 ± 3 (384) (62, 575) | 144 ± 15; 160 ± 11 (P = 0.40) |
20 wk | 177 ± 10 (18)a | 156 ± 5 (19)a | 364 ± 36 (16)b | 165 ± 3 (378) (64, 492) | 144 ± 17; 163 ± 13 (P = 0.40) |
24 wk | 175 ± 10 (18)a | 162 ± 8 (19)a | 387 ± 33 (16)b | 162 ± 3 (375) (40, 599) | 131 ± 9; 128 ± 13 (P = 0.83) |
Insulin (ng/ml) | |||||
8 wk | 0.07 ± 0.02 (9)a | 0.96 ± 0.17 (15)b | 1.81 ± 0.41 (7)c | 1.31 ± 0.06 (384) (0.01, 9.71) | 1.45 ± 0.31; 1.36 ± 0.28 (P = 0.83) |
12 wk | 0.22 ± 0.07 (13)a | 1.12 ± 0.15 (19)b | 0.98 ± 0.33 (9)b | 1.55 ± 0.08 (376) (0.06, 12.36) | 0.80 ± 0.14; 1.28 ± 0.17 (P = 0.05) |
16 wk | 0.35 ± 0.09 (18)a | 1.24 ± 0.13 (19)b | 0.98 ± 0.26 (15)b | 2.17 ± 0.11 (381) (0.07, 15.03) | 1.19 ± 0.23; 1.94 ± 0.43 (P = 0.20) |
20 wk | 0.42 ± 0.11 (18)a | 2.14 ± 0.26 (19)b | 1.56 ± 0.41 (16)b | 2.39 ± 0.15 (376) (0.02, 23.18) | 1.12 ± 0.36; 2.35 ± 0.47 (P = 0.06) |
24 wk | 0.41 ± 0.10 (10)a | 2.78 ± 0.55 (16)b | 2.31 ± 0.56 (13)b | 2.70 ± 0.16 (371) (0.06, 23.97) | 2.59 ± 1.10; 5.13 ± 2.10 (P = 0.30) |
Body weight (g) | |||||
8 wk | 22 ± 0.4 (14)a | 30 ± 0.5 (15)b | 31 ± 0.5 (7)b | 29 ± 0.2 (385) (20, 40) | 30 ± 1.1; 29 ± 0.9 (P = 0.33) |
12 wk | 24 ± 0.5 (18)a | 33 ± 0.6 (19)b | 32 ± 0.6 (16)b | 33 ± 0.2 (385) (23, 45) | 33 ± 1.2; 33 ± 1.2 (P = 0.65) |
16 wk | 25 ± 0.5 (18)a | 36 ± 0.7 (19)b | 34 ± 0.8 (16)b | 35 ± 0.2 (383) (24, 49) | 35 ± 1.5; 36 ± 1.3 (P = 0.66) |
20 wk | 27 ± 0.5 (18)a | 38 ± 0.7 (19)b | 36 ± 1.0 (16)c | 37 ± 0.3 (378) (25, 52) | 36 ± 2.0; 38 ± 1.1 (P = 0.39) |
24 wk | 28 ± 0.4 (18)a | 41 ± 0.6 (19)b | 36 ± 1.4 (16)c | 39 ± 0.3 (373) (25, 59) | 38 ± 2.2; 41 ± 1.3 (P = 0.26) |
Fat pad & Carcass weights (g) | |||||
IG | 0.34 ± 0.02 (18)a | 1.37 ± 0.07 (19)b | 0.69 ± 0.15 (16)c | 0.99 ± 0.03 (372) (0.07, 2.66) | 0.64 ± 0.14; 1.14 ± 0.10 (P = 0.01) |
ED | 0.43 ± 0.03 (18)a | 1.86 ± 0.07 (19)b | 0.98 ± 0.23 (16)c | 1.41 ± 0.03 (372) (0.19, 3.21) | 1.11 ± 0.25; 1.69 ± 0.19 (P = 0.08) |
MS | 0.11 ± 0.01 (18)a | 0.60 ± 0.03 (19)b | 0.24 ± 0.06 (16)c | 0.40 ± 0.01 (372) (0.07, 1.30) | 0.35 ± 0.12; 0.46 ± 0.04 (P = 0.40) |
RP | 0.12 ± 0.01 (18)a | 0.64 ± 0.02 (19)b | 0.26 ± 0.06 (16)c | 0.43 ± 0.01 (371) (0.05, 1.47) | 0.31 ± 0.07; 0.63 ± 0.13 (P = 0.05) |
SC | 0.14 ± 0.01 (18)a | 0.72 ± 0.04 (19)b | 0.32 ± 0.09 (16)c | 0.50 ± 0.02 (372) (0.05, 3.26) | 0.32 ± 0.08; 0.59 ± 0.06 (P = 0.01) |
Sum | 1.14 ± 0.06 (18)a | 5.17 ± 0.20 (19)b | 2.34 ± 0.55 (16)c | 3.72 ± 0.09 (371) (0.52, 8.59) | 2.69 ± 0.61; 4.51 ± 0.31 (P = 0.02) |
Carcass | 26 ± 0.4 (18)a | 34 ± 0.5 (19)b | 31 ± 1.0 (16)c | 33 ± 0.2 (371) (23, 47) | 34 ± 1.8; 34 ± 1.0 (P = 0.91) |