Table 2 Canonical pathways identified by IPA associated with differentially expressed genes of 4 days post-infection (p ≤ 0.05; fold times ≥ 1.2 times. +: activation; -: inhibition).
Ingenuity signaling Pathways | -log (p-value) | Ratio | Up/down | Effect | Function (From IPA) |
|---|---|---|---|---|---|
NRF2-mediated Oxidative Stress Response | 5.25E00 | 4.37E-01 | 24/56 | + | Cell Death; Developmental Disorder |
Antigen Presentation Pathway | 3.79E00 | 4.36E-01 | 17/0 | + | Genetic Disorder; Immunological Disease Gene Expression; Infection Mechanism |
Estrogen Receptor Signaling | 3.47E00 | 4.37E-01 | 4/48 | - | Cellular Growth and Proliferation |
Xenobiotic Metabolism Signaling | 3.57E00 | 3.60E-01 | 30/75 | - | Lipid Metabol is m; Small Molecule Biochemistry Vitamin and Mineral Metabolism |
IL- 9 Signaling | 3.4E00 | 5.41E-01 | 12/8 | + | Cell Death; Cellular Growth and Proliferation |
EIF2 Signaling | 3.32E00 | 4.2E-01 | 10/32 | - | Protein Synthesis; Amino Acid Metabolism; Post-Translational Modification |
Glucocorticoid Receptor Signaling | 2.79E00 | 3.64E 01 | 39/63 | + | Cellular Development; Gene Expression; Cellular Growth and Proliferation |
Regulation of eIF4 and p70S6K Signaling | 2.74E00 | 3.85E-01 | 11/39 | - | Gene Expression; Protein Synthesis and Cancer |
Role of PKR in Interferon Induction and Antiviral | 2.73E00 | 5E-01 | 17/6 | + | Cell Death; Cellular Development; Immune Response |
DNA Methylation, Transcriptional Repression Signaling | 2.51E00 | 5.65E-01 | 0/13 | - | Gene Expression; DNA Replication, Recombination and Repair; Cell Cycle |
IL-4 signaling | 2.47E00 | 4.46E -01 | 19/14 | + | Cellular Development; Hematopoietic |
LPS/IL-1 Mediated Inhibition of RXR Function | 2.39E00 | 3.49E-01 | 27/48 | - | Lipid Metabolism;Small Molecule Biochemistry |
Retinoic acid Mediated Apoptosis Signaling | 2.35E00 | 4.09E-01 | 12/6 | + | Cell Death; Embryonic Development; Cell Morphology |
EGF Signaling | 2.35E00 | 4.69E- 01 | 9/14 | + | Gene Expression; Cell cycle, Cellular Growth and Proliferation |
Interferon Signaling | 2.29E00 | 5.33E-01 | 15/1 | + | Organism Injury and Inflammatory Response Cellular Growth and Proliferation |
P38 MAPK Signaling | 2.21E00 | 4.23E-01 | 21/20 | + | Gene Expression; Cell Death; Cell Signaling |
LPS-stimulated MAPK Signaling | 2.2E00 | 4.23E-01 | 15/18 | + | Cell Death; Gene Expression; Cellular Development. |
Insulin Receptor Signaling | 2.01E00 | 3.86E-01 | 14/40 | - | Cancer; Carbohydrate Metabolism; Molecular Transport |
Acute Phase Response Signaling | 2E00 | 3.96E-01 | 10/9 | + | Hematological System Development and Function; Hematological Disease; Cell Death |
mTOR Signaling | 1.99E00 | 3.88E-01 | 41/28 | + | Gene Expression; Protein Synthesis; Cell Morphology |
LXR/RXR Activation | 1.88E00 | 4.14E-01 | 9/20 | - | Lipid Metabolism; Molecular Transport; Small Molecule Biochemistry |