Figure 3
From: An integrated functional genomic study of acute phenobarbital exposure in the rat
Plasma lipoprotein profile. PLS plots correlating metabolic profiles with dose of PB at day 14 using 1H-NMR spectroscopy of blood plasma (A). Key: Control (filled square), 50 ppm (open circle), 500 ppm (filled triangle), 1000 ppm (open square). Overlaid 1H-NMR spectra from the region containing the terminal methyl group of fatty acids in blood plasma (B). A change in the shape of the peak, with an increase in the proportion of lower chemical shift, higher density lipoprotein with increasing dose of PB is clearly detected. This is characteristic of an increase in high density lipoprotein particles relative to low density lipoprotein particles.