Figure 3

Alignment of TvBspA with TMD and similar cytoplasmic tails with potential signal for endocytosis. (A) The 21 identified TvBspA with similar CT (sequence and length) all ending with the pattern [DE]FG (green). Most sequences possess a motif related to [DE]XXXL [LI] (blue), a dileucine-based type endocystosis and lysososmal-like sorting signal (see text). Residues replacing [DE] in known functional endocytosis signal in other species are also shown in blue (see text). (B) The 15 identified TvBspA sequences with a similar TMD (yellow) and CT. Most entries share the FDNPX[YF] (blue) an NPXY-type endocytosis signal (see text). The five entries that are part of subfamily #228 (bottom five sequences, see text and Table 2) also share a more similar TMD compared to the other 10 entries. Conserved residues in the TMD differentiating the two sets of sequences are highlighted in dark blue.