Table 1 Comparative analysis of TF binding specificity estimated based on three methods. Specificity threshold estimates by the uniform noise model [15], by ChIP -qPCR [15] and by the best-fit GDP function. The uniform random model-based estimations of the threshold values defined at FDR <5%. TF binding specificity threshold t was estimated based on the best-fit double truncated GDP function. The last two columns of the table shows that GDP-model could improve the specificity estimates providing by the Poisson model and ChIP-q-PCR assay.

From: Statistics of protein-DNA binding and the total number of binding sites for a transcription factor in the mammalian genome