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Table 3 Key milestones of computational protein complex detection

From: Computational approaches for detecting protein complexes from protein interaction networks: a survey

Methods Main contributions
MCODE [27] MCODE pioneered the computational detection of protein complexes from PPI networks.
MCL [30, 31] MCL is a widely used method [3336] with good convergence and robustness [32]
Krogan et al. [33] They provided and exploited a comprehensive TAP dataset for computational protein complex detection.
Gavin et al. [3] In addition to providing a TAP dataset widely used for protein complex detection, they described the inherent organization of protein complexes with core-attachment structures.
Sharan et al. [7880] They systematically conducted cross-species analysis of PPI networks to derive evolutionary information for protein complex detection.