3D-interologs: an evolution database of physical protein- protein interactions across multiple genomes

BMC Genomics

Table 3 3D-interologs search results using human calcineurin heterodimer as the query

Interactor1	Interactor2	Species	Z score	Rank	P / N^a	RSS of BP^b	RSS of CC^c	Interacting domain1	Interacting domain2
P48456	P48451	Fruit fly	8.98	1	P	0.89	0.85	Metallophos	efand
P23287	P25296	Yeast	8.25	1	P	0.88	1.00	Metallophos	efand
P14747	P25296	Yeast	7.95	2	P	0.88	1.00	Metallophos	efand
Q12705	Q9UU93	Yeast	7.94	1	P	- ^d	0.78	Metallophos	efand
P48456	P47948	Fruit fly	4.42	16	N	0.41	0.30	Metallophos	efand
P48456	P47949	Fruit fly	4.38	17	N	0.41	0.30	Metallophos	efand
P48456	P49258	Fruit fly	3.99	23	P	0.41	0.56	Metallophos	efand
P48456	Q9VQH2	Fruit fly	3.94	25	N	0.49	0.33	Metallophos	efand
Q8IAM8	P62203	Plasmdium falciparum	3.79	2	P	-	-	Metallophos	efand
P48456	P48593	Fruit fly	3.72	31	P	0.35	0.56	Metallophos	efand
P48456	A1ZAE1	Fruit fly	3.59	34	N	0.00	0.30	Metallophos	efand
Q27889	P48593	Fruit fly	3.42	40	P	-	-	Metallophos	efand
P23287	P06787	Yeast	3.36	5	P	0.61	0.88	Metallophos	efand
P48456	Q9VMT2	Fruit fly	3.03	50	N	0.41	0.30	Metallophos	efand
P48456	Q7K860	Fruit fly	2.99	53	N	0.41	0.30	Metallophos	efand
P14747	P06787	Yeast	2.86	6	P	0.61	0.88	Metallophos	efand
P48454	Q9NP86	Human	2.33	90	N	-	0.00	Metallophos	efand
Q08209	Q9NP86	Human	2.31	91	N	0.41	0.00	Metallophos	efand
P16298	Q9NP86	Human	2.31	91	N	-	0.00	Metallophos	efand

3D-interologs infers 10 positive and 9 negative protein-protein interactions by human calcineurin heterodimer (PDB code 1aui), including calmodulin-dependent calcineurin A subunit alpha isoform (chain A with interacting domain Metallophos) and calcineurin subunit B type 1 (chain B with interacting domain efhand), searching on Integr8 database.^a PPI is a positive (P, recorded in IntACT database) or negative case (N, RSS of cellular component is less than 0.4).^b,c The relative specificity similarity (RSS) scores, proposed by Wu et al.[43], of Gene Ontology biologicalprocess (BP) and cellular component (CC), respectively. ^d The protein pair is without Gene Ontology annotations in BP or CC.

ISSN: 1471-2164