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Figure 1 | BMC Genomics

Figure 1

From: How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics

Figure 1

Localization of differentially protonated residues in catB Cartoon representation of the catB tertiary structure showing differentially protonated residues as green sticks. Protonation states were assigned to represent acidic (pH 5.5) or alkaline conditions (pH 8) based on pKa calculations with PROPKA on the catB crystal structure. The L and R domains of the protein are highlighted blue and red, respectively. The occluding loop (residues 106-124) a structural element found only in catB within its family, is represented in yellow.

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BMC Genomics

ISSN: 1471-2164

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