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Figure 4 | BMC Genomics

Figure 4

From: The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis

Figure 4

The double negative feedback loop of SOX2 and miR-145. (A) An illustrative drawing showing the double negative feedback loop of SOX2 and microRNA 145. Negative signs and upside down T line drawing indicate inhibitive action. Both SOX2 and miR-145 can receive separate input signals (signal A or signal B). (B) Theoretical bistable output of this double negative feedback loop. Depending on the strength of the input signal A or B, the system could toggle between two stable states: the signal A-SOX2 or the signal B-miR-145 states.

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BMC Genomics

ISSN: 1471-2164

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