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Table 2 Genomic segments significantly over/under-expressed in Mk cells (pool 'A') vs. CD34+ cells (pool 'B')

From: TRAM (Transcriptome Mapper): database-driven creation and analysis of transcriptome maps from multiple sources

Chr and Location

Segment Start

Segment End

'A'/'B' Ratio

q-value

Genes in the segment

chr2 2q23-q24

160,250,001

160,750,000

0.398

0.00024

BAZ2B-MARCH7-CD302- LY75-

chr4 4q11-q12

57,500,001

58,000,000

0.421

0.00039

HOPX- SPINK2-REST- C4orf14- POLR2B+IGFBP7-

chr4 4p15.32

15,500,001

16,000,000

0.427

0.00039

FBXL5-BST1- CD38-FGFBP1- FGFBP2-PROM1-

chr6 6p21.3

32,250,001

32,750,000

0.434

0.00079

C6orf10+ BTNL2-HLADRA- HLADRB1- HLADQA1-HLADQB1- HLADQA2- HLADQB2-

chrX Xp11.23

47,000,001

47,500,000

1.806

0.00505

NDUFB11+ RBM10+ UBA1+INE1+USP11- ZNF157+ ZNF41+ ARAF+SYN1+ TIMP1+CFP+ ELK1+

chr11 11q12.2

61,250,001

61,750,000

1.859

0.00573

C11orf66+ SYT7- DAGLA- C11orf9+ C11orf10+ FEN1+FADS1+ FADS2+FADS3- RAB3IL1+ BEST1-FTH1+

chr16 16p12.1

28,500,001

29,000,000

1.877

0.00248

CLN3+ APOB48R+ IL27+NUPR1+CCDC101- SULT1A2+SULT1A1+EIF3C- ATXN2L+ TUFM+ SH2B1-ATP2A1+RABEP2- CD19- NFATC2IP+ SPNS1+LAT+

chr17 17q23

62,000,001

62,500,000

1.957

0.00381

CD79B-SCN4A-C17orf72+ ICAM2+ERN1+ TEX2+PECAM1+C17orf60- POLG2+ DDX5+

chr6 6p21-1

43,500,001

44,000,000

2.196

0.00235

XPO5-POLH+ GTPBP2+ MAD2L1BP+MRPS18A+ VEGFA+ C6orf223+

chr5 5qter

178,750,001

179,250,000

2.367

0.00222

ADAMTS2-RUFY1+HNRNPH1+ CANX+ MAML1+LTC4S+ MGAT4B+SQSTM1+

chr11 11p15

5,000,001

5,500,000

2.384

0.00796

MMP26- OR51L1+ OR52J3+ OR52A1+ HBB+HBD+ Hs.20205+ HBG1+HBG2+ HBE1+ OR51B4+ OR51B2- OR51B6+ OR51M1- OR51I1+ OR51I2+

chr17 17p13.2

4,750,001

5,250,000

2.620

0.00796

MINK1+ CHRNE+GP1BA+SLC25A11+ RNF167+PFN1+ENO3+ SPAG7+ CAMTA2+KIF1C+GPR172B+ ZFP3- ZNF232- USP6+ ZNF594- RABEP1-

chr4 4q13-q21

74,500,001

75,000,000

9.226

0.00000

IL8+ CXCL6+PF4V1+ CXCL1+ PF4+ PPBP+CXCL5+CXCL3+PPBPL2+CXCL2+

  1. Chr: chromosome; Segment Start/End: chromosomal coordinates for each segment. Bold and '+': over-expressed gene; bold and '-': under-expressed gene; '+' or '-': gene expression value higher or lower than the median value, respectively. Analysis was performed using default parameters (see "Methods" section). Segments are sorted by increasing 'A'/'B' ratio. In the 'Map' mode, TRAM displays UniGene EST clusters (with the prefix "Hs." in the case of H. sapiens) only if they have an expression value. Five out of a total of 18 segments are not shown for simplicity, because their over-expressed genes are overlapping with those highlighted in the listed regions. The complete results for this model are available along with TRAM software.
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BMC Genomics

ISSN: 1471-2164

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