Figure 3

Chromosomes were typed based on CNV signatures. Diagnostic CNV were selected based on the criteria that they were at least 500 bp in length, represented by at least 5 oligonucleotide probes, and had log2ratios of at least +/- 1 (tolerance of 0.2) in at least 5 strains. Up to two CNV meeting the criteria were selected for each chromosome based on their ability to differentiate between the strains; i.e. the CNV that separated the strains into the highest number of groups compared to other candidate diagnostic CNV were selected. Thus, for each chromosome there were a finite number of signature types to which strains were assigned based upon the presence/absence of the diagnostic CNV's the direction of change (log2ratio +/- 0.8). Each chromosome type is represented by a different color, with CL-Brener always assigned to type 'A' (blue). The strains were then sorted based on the overall similarity of their chromosome types, taken together, relative to CL-Brener.