Figure 5

Turnover of binding sites is increased in the vicinity of adipogenic genes. (A) Bar diagrams representing the fraction of transcription factor binding turnover events (C/EBPα: light blue, PPARγ: light red) and retained binding sites (C/EBPα: blue, PPARγ: red) broken up by expression clusters as in Fig. 4. *P= 8.183*10^-4 (clusters 3+4 vs. all other clusters (Wilcoxon test) (B) Histograms illustrating the fraction (y axis) of human genes within a particular cluster that have the indicated number (x axis) of human-specific binding sites within 50 kb of the TSS.