Figure 7
Correlation between retention, consensus motifs and mouse-human sequence identity. (A) Retention of mouse C/EBPα and PPARγ binding sites in human adipocytes with or without a corresponding consensus site within the orthologous human regions. *P = 8.125*10^-08 (Fisher Exact Test); #P = 3.344*10^-07 (Fisher Exact Test); ^P = 5.533*10^-06 (Fisher Exact Test); ~P = 1.935*10^-06 (Fisher Exact Test). (B) Retention of mouse C/EBPα binding sites in human adipocytes with or without a PPARγ consensus site; and conversely, retention of PPARγ binding sites in human adipocytes with or without a C/EBPα consensus site. *P = 0.009 (C/EBPα consensus site vs. no consensus site (Fisher Exact Test)). (C) Correlation between binding site retention and overall mouse-human DNA sequence identity of the aligned region. Sites were divided into four groups from lowest to highest mouse-human sequence identity, and the fraction of retained sites in each group is shown on the y axis. (D) Fraction of sites having predicted C/EBP consensus sites, broken up by overall sequence identify and whether the sites are overlapped or not. (E) Fraction of sites having predicted PPAR consensus sites, broken up by overall sequence identify and whether the sites are overlapped or not. Numbers above the bars correspond to the total number of mouse sites in each group.