Time-series clustering of gene expression in irradiated and bystander fibroblasts: an application of FBPA clustering

Table 4 PANTHER gene ontology analysis on STEM clustering of gene expression data after direct irradiation

Biological Process	Cluster
	1	2	3	4	5	6
Intracellular signaling cascade	NS	NS	1.03 × 10^-6 (10)	NS	NS	NS
Cytokine and chemokine mediated signaling pathway	NS	NS	1.04 × 10^-6 (7)	NS	NS	NS
Apoptosis	NS	NS	1.25 × 10^-6 (8)	NS	NS	NS
Ligand-mediated signaling	NS	NS	1.34 × 10^-6 (8)	NS	NS	NS
NF-kappaB cascade	NS	NS	2.10 × 10^-6 (5)	NS	NS	NS
Immunity and defense	NS	NS	1.07 × 10^-5 (10)	NS	NS	NS
Signal transduction	4.09 × 10^-2 (9)	NS	3.63 × 10^-5 (14)	NS	4.09 × 10^-2 (9)	NS
Macrophage-mediated immunity	NS	NS	4.38 × 10^-5 (5)	NS	NS	NS
Cell proliferation and differentiation	NS	NS	1.79 × 10^-4 (8)	NS	NS	NS
MAPKKK cascade	NS	NS	2.10 × 10^-4 (5)	NS	NS	NS
Cell communication	NS	NS	2.75 × 10^-4 (9)	NS	NS	NS
Cell surface receptor mediated signal transduction	NS	NS	3.62 × 10^-4 (10)	NS	4.79 × 10^-2 (7)	NS
Inhibition of apoptosis	NS	NS	1.27 × 10^-3 (4)	NS	NS	NS
Granulocyte-mediated immunity	NS	NS	5.75 × 10^-3 (3)	NS	NS	NS
T-cell mediated immunity	NS	NS	6.42 × 10^-3 (4)	NS	NS	NS
JNK cascade	NS	NS	6.82 × 10^-3 (3)	NS	NS	NS
Cell cycle control	NS	NS	8.58 × 10^-3 (5)	NS	NS	NS
JAK-STAT cascade	NS	NS	1.81 × 10^-2 (3)	NS	NS	NS
Calcium mediated signaling	NS	NS	4.52 × 10^-2 (3)	NS	NS	NS

Significant PANTHER biological processes categories, p-values are Bonferroni corrected, p-values < 0.05 are shown. The number of genes in each category is shown in parentheses. NS is Not Significant.

ISSN: 1471-2164