Figure 6

Network analysis of the differentially-expressed genes between resistant and susceptible lines. Network analysis was performed with IPA (n = 335 genes, n = 287 IPA network eligible genes). The colours represent the expression level: the genes over-expressed in resistant animals are in red whereas the down-regulated genes are in green. (A) Twenty-eight genes belonged to network A that scores 42. The main biological functions are lipid metabolism, molecular transport and small molecule biochemistry. (B) Thirty-five genes are present in network B. The original network involved twenty-six genes and scores 39. It is characterised by cell movement, haematological system development and function, and immune cell trafficking. We could add seven DE expressed genes of interest (akt1, cd59, eif4ebp1, hspa6, itga5, osmr and rarα) to this network through five other genes, with direct relationships with genes involved in this network.