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Table 4 Genes showing hormonal and genotype transcriptional differences, but without co-dependence

From: The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

  

Genotype Effect

Hormonal Effect

 

Genotype

Gene Target

FC (95%CI)

Direction

FC (95%CI)

Direction

p -value

GKO

Abca8a

1.35(1.15-1.58)

Down

1.58(1.35-1.85)

Down

1.39E-07

GKO

Ddx3y

1.52(1.31-1.77)

Down

1.21(1.04-1.40)

Down

1.52E-05

GKO

Kiss1

1.96(1.64-2.35)

Up

12.15(10.15-14.55)

Down

4.29E-46

GKO

Tmem144

1.86(1.60-2.16)

Down

1.28(1.10-1.48)

Down

1.51E-10

KKO

Abca8a

1.21(1.06-1.37)

Up

1.64(1.45-1.86)

Down

1.75E-09

  1. FC = fold change, CI = confidence interval, Dir = direction of change relative to WT (genotype panel) and T (hormone panel). GKO = GPR54 knockout, KKO = Kisspeptin knockout
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BMC Genomics

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