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Table 4 Genes showing hormonal and genotype transcriptional differences, but without co-dependence

From: The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

   Genotype Effect Hormonal Effect  
Genotype Gene Target FC (95%CI) Direction FC (95%CI) Direction p -value
GKO Abca8a 1.35(1.15-1.58) Down 1.58(1.35-1.85) Down 1.39E-07
GKO Ddx3y 1.52(1.31-1.77) Down 1.21(1.04-1.40) Down 1.52E-05
GKO Kiss1 1.96(1.64-2.35) Up 12.15(10.15-14.55) Down 4.29E-46
GKO Tmem144 1.86(1.60-2.16) Down 1.28(1.10-1.48) Down 1.51E-10
KKO Abca8a 1.21(1.06-1.37) Up 1.64(1.45-1.86) Down 1.75E-09
  1. FC = fold change, CI = confidence interval, Dir = direction of change relative to WT (genotype panel) and T (hormone panel). GKO = GPR54 knockout, KKO = Kisspeptin knockout
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BMC Genomics

ISSN: 1471-2164

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