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Table 10 Age-regulated adipocyte gene expression

From: Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

   Bone marrow Epididymal  
Symbol Entrez Gene Name 14M 18M 14M 18M p -value (Age)
TRIB2 tribbles homolog 2 (Drosophila) 3.0 1.2 1.8 -1.2 1.78E-05
TNFα tumor necrosis factor α 2.4 -1.5 -2.4 -2.2 0.00013
IRS2 insulin receptor substrate 2 2.0 -1.1 -4.3 -2.9 0.00018
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.8 1.2 1.7 1.5 2.12E-06
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.4 -2.1 -3.8 -5.6 4.87E-07
PPARGC1α peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.4 -1.1 -1.0 2.0 0.0024
IL1β interleukin 1, beta 1.4 -1.5 -2.3 -2.2 0.00026
FN1 fibronectin 1 1.4 -1.2 7.1 -3.2 4.20E-07
PARP2 poly (ADP-ribose) polymerase 2 1.4 1.2 1.3 1.2 0.0018
CCND1 cyclin D1 1.3 1.1 2.5 -1.6 0.00062
INSIG1 insulin induced gene 1 1.3 1.5 1.3 2.8 0.0057
FGF10 fibroblast growth factor 10 1.2 1.2 -2.6 1.0 0.0031
DDIT3 DNA-damage-inducible transcript 3 1.2 -2.1 -1.8 -1.2 0.0036
C3 complement component 3 1.0 -1.4 2.1 -1.3 0.00052
PNPLA2 patatin-like phospholipase domain containing 2 -1.0 -1.6 -1.4 -1.2 0.0049
ABHD5 αβ hydrolase domain containing 5 -1.0 -1.4 -2.0 -1.1 0.00059
GPR109A G protein-coupled receptor 109A -1.2 -4.5 -10.6 -2.7 2.68E-08
RARα retinoic acid receptor, alpha -1.3 -2.4 1.1 -1.5 3.42E-05
RETNLα resistin like alpha -1.3 -1.1 3.0 -10.8 8.46E-08
ARL4A ADP-ribosylation factor-like 4A -1.3 1.3 -2.0 1.0 3.30E-05
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -1.4 -1.6 -1.6 -1.2 0.0024
LAMA4 laminin, alpha 4 -1.4 -1.4 -1.4 -1.2 0.0065
C/EBPα CCAAT/enhancer binding protein, alpha -1.5 -1.4 -1.3 1.1 0.0062
FABP4 fatty acid binding protein 4, adipocyte -1.5 -2.6 -1.2 -1.3 0.0026
AR androgen receptor -1.8 -2.0 -1.5 -1.8 0.00026
LEP leptin -2.0 -1.8 1.0 1.6 0.0017
IL6 interleukin 6 -2.0 -2.1 -20.5 -5.6 8.65E-07
  1. The list includes the genes that change with age in both bone marrow and epididymal adipocytes. The set of the 27 regulated genes was selected on the basis of their fold changes across age in both adipocyte populations sorted using Partek Genome Suit software and IPA. The significance of differences was measured by two-way ANOVA. A low value in p indicates the gene is differentially expressed with respect to age. The comparison included 14-month (14M) and 18-month-old (18M) compared to 6-month-old.