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Table 4 Top regulated pathways in bone marrow and epididymal adipocytes with age

From: Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

   

Genes

Genes assigned

 

Pathway

Cell type

Age (M)

Up

Down

In pathway

Ratio*

-Log10 ( p value)**

Adipocyte differentiation

Bone marrow

14M

18

12

30

0.36

1.922

  

18M

11

19

 

0.486

4.436

 

Epididymal

14M

9

21

30

0.61

6.019

  

18M

8

22

 

0.46

2.498

Lipolysis

Bone marrow

14M

6

7

13

0.289

1.347

  

18M

5

8

 

0.263

0.87

 

Epididymal

14M

2

11

13

0.342

1.203

  

18M

2

11

 

0.289

0.659

Mitochondria dysfunction

Bone marrow

14M

12

18

30

0.237

1.115

  

18M

13

17

 

0.323

3.364

 

Epididymal

14M

3

27

30

0.24

0.487

  

18M

21

9

 

0.226

0.28

  1. For each gene, the fold change of expression of 14-month-old (14M) and 18-month-old (18M) was calculated versus 6-month-old (6M). Pathways that have significant association with the whole set of regulated genes in bone marrow and epididymal adipocytes with age were assessed using IPA software. * Ratio of altered genes in bone marrow adipocytes to assigned pathway. **The p-value was calculated by IPA using Fisher's Exact Test. A threshold of 1.30 was selected (p < 0.05)
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BMC Genomics

ISSN: 1471-2164

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