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Table 8 Top regulated adipocyte genes in bone marrow adipocytes with age

From: Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

Symbol Entrez Gene Name 14M 18M p-value (cell type*age)
TNFα tumor necrosis factor α 2.37 -1.38 1.47E-05
FOXO1 forkhead box O1 1.99 1.17 0.0006
IRS2 insulin receptor substrate 2 1.93 -1.08 0.0008
C/EBPβ CCAAT/enhancer binding protein beta 1.79 -1.23 1.22E-05
CD36 fatty acid translocase 1.38 2.00 0.001
PPARγ peroxisome proliferator-activated receptor gamma 1.36 1.08 0.003
PLIN3 perilipin 3, TIP47 1.25 1.04 0.007
SOD2 superoxide dismutase 2, mitochondrial 1.24 -1.09 0.001
UCP2 uncoupling protein 2 1.24 1.18 8.1E-06
LIPE lipase, hormone sensitive 1.23 -1.27 2.1E-05
SERPINE1 plasminogen activator inhibitor type 1 1.21 -1.30 0.0004
GPX1 glutathione peroxidase 1 1.04 1.23 0.0002
SLC2A4 GLUT-4 -1.11 1.30 0.04
CFD adipsin -1.12 1.25 0.002
FABP4 fatty acid binding protein 4, adipocyte -1.52 -2.46 0.001
PTPN11 protein tyrosine11 -1.58 -1.21 0.0006
ADIPOR2 adiponectin receptor 2 -1.66 -1.44 0.001
LEPR leptin receptor -1.94 1.44 0.002
IL6 interleukin 6 (interferon, beta 2) -2.19 -1.91 8.34E-05
ADIPOQ adiponectin -2.25 -1.88 0.01
  1. The list includes the adipocyte genes that change with age in bone marrow adipocytes. The set of regulated genes was selected on the basis of their expression in adipose according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in bone marrow adipocytes from mice. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA.