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Table 9 Top regulated adipocyte genes in epididymal adipocytes with age

From: Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

  Entrez Gene Name 14M 18M P value (cell type*age)
UCP2 uncoupling protein 2 2.3 1.3 8.1E-061
LEPR leptin receptor 1.3 -1.1 0.02
FGFR1 fibroblast growth factor receptor 1 1.3 -1.5 0.03
PLIN3 perilipin 3, TIP47 1.2 1.6 0.0007
PPARγ peroxisome proliferator-activated receptor gamma 1.1 1.8 0.0003
PLIN2 Perilipin 2, adipophilin, ADFP 1 1.7 5.8E-05
ADIPOQ Adiponectin -1.2 1.2 0.01
FABP4 fatty acid binding protein 4, adipocyte -1.2 -1.3 0.05
C/EBPα CCAAT/enhancer binding protein, alpha -1.3 1.1 0.01
PPARGC1α peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -1.5 2 1.4E-05
ADIPOR2 adiponectin receptor 2 -1.6 -1.1 0.001
SOD2 superoxide dismutase 2, mitochondrial -1.8 -1.1 0.0001
TNFα TNFα -2.3 -2.1 0.0001
C/EBPβ CCAAT/enhancer binding protein, beta -2.4 -1 1.4E-05
IRS2 insulin receptor substrate 2 -4.3 -2.8 1.2E-05
SERPINE1 plasminogen activator inhibitor type 1 -7.3 -4.3 0.0004
IL6 interleukin 6 -19.8 -4.8 8.3E-05
  1. The list includes the adipocyte genes that change with age in epididymal adipocytes. The set of regulated genes was selected on the basis of their expression in adipose according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in epididymal adipocytes. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA.