Figure 5

Phylogenetic analysis of the paralogous ePKs groups of S. Mansoni. The catalytic domain of S. mansoni ePKs was used to construct a distance-based phylogenetic tree using PHYLIP programs. Some ePK were excluded from the tree after filtered the alighments to keep proteins with 30% to 98% pairwise sequence identity. The major ePK groups are color coded and include: CaMK (dark blue), CMGC (orange), TK (red), AGC (green), STE (pink), TKL (light blue), CK1 (yellow), and RGC (light pink). Functional classification is indicated individually in the protein. Proteins with experimental evidence () and those predicted to be inactive (⊗) due one or more substitutions in important residues in the catalytic domain are indicated. Bootstrap values (100 replicates) equal or higher than 80% are indicated (●).