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Table 2 Apolar metabolites significantly affected by TCDD (p < 0.01) and average fold change ratio between treatments (TCDD vs. DMSO).

From: An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

GC-MS

Ratio TCDD/DMSO (RTD)

C12:0

0.78

C14:0

0.72

C14:1a

0.70

C14:1b

0.29

C16:1 (n-6)

0.63

C16:1 (n-9)

0.62

C17:0

1.20

C18:0

1.27

C18:1 (n-9)

0.78

C18:1c

0.72

C18:2a

0.71

C18:2b

0.63

C18:2c

1.29

C18:2d

0.64

C18:2e

0.63

C20:1b

0.79

C20:2a

0.74

C20:2b

0.70

C20:3a

0.80

C20:3b

0.64

C22:2

0.61

C22:3a

0.73

1H NMR

Ratio TCDD/DMSO (RTD)

Total triglycerides

0.51

Total cholesterol ester

0.69

  1. *Underscore letters indicate isomers (unidentified).
  2. Individual passage number results are in Additional File 1 (Tables S3 and S4).
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BMC Genomics

ISSN: 1471-2164

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