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Table 4 Polar metabolites significantly affected by TCDD exposure.

From: An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Metabolite Change fold (1H NMR p < 0.01) Change fold (LC-MS p < 0.01)
Leucine, Isoleucine 0.69 0.64
Valine 0.72 0.69
Alanine 0.68 --
N-acetyl-aspartate 0.68 0.72
Glutamate 0.79 0.80
Glutamine 0.69 --
Glycine 0.72 --
Aspartate 0.66 --
Serine 0.65 --
Tyrosine 0.58 0.44
Proline -- 0.54
Tryptophan -- 0.79
Lactate 0.49 --
Spermidine -- 0.24
N1-acetyl-spermidine -- 0.59
Pantothenic acid -- 0.62
Creatine/Phosphocreatine 0.66 --
Propyonylcarnitineb -- 0.66
Butyrylcarnitine -- 0.58
Nucleotides (AXP and UMP) 0.3-0.6 --
UMP -- 0.71
AMP -- 0.67
Oxidized glutathione 1.26 1.31
Reduced glutathione 1.58 1.23
Taurine 1.37 --
Citrate 1.46 1.68
UDP-N-acetyl-galactosamine/glucosamine* -- 1.48
  1. The fold changes are given as the ratio of the average content in TCDD and in DMSO. Individual passage number results are in Additional File 1 (Tables S5 and S6).
  2. *Tentatively identified