Table 1 Top Metabolic Processes Enriched in Transcriptomic and Proteomic Profiling of the Gcgr-/- Mouse Liver
| Â | Â | Adj. p-value | Sample frequency | Background frequency |
|---|---|---|---|---|
GO:0008152 metabolism Process | mRNA | 7.80E-80 | 438/899 (48.7%) | 6938/34273 (20.2%) |
| Â | Protein | 4.14E-29 | 70/86 (81.4%) | Â |
   GO:0009058 biosynthetic process | mRNA | 2.32E-27 | 207/899 (23.0%) | 3429/34273 (10.0%) |
| Â | Protein | 3.67E-06 | 29/86 (33.7%) | Â |
GO:0009056 catabolic process | mRNA | 4.59E-10 | 63/899 (7.0%) | 839/34273 (2.4%) |
| Â | Protein | 1.97E-20 | 31/86 (36.0%) | Â |
GO:0005975 carbohydrate metabolic process | mRNA | 2.56E-05 | 36/899 (4.0%) | 456/34273 (1.3%) |
| Â | Protein | 1.71E-07 | 13/86 (15.1%) | Â |
   GO:0016051 carbohydrate biosynthetic process | mRNA | 5.18E-04 | 11/438 (2.5%) | 107/34273 (0.3%) |
| Â | Protein | 4.38E-07 | 8/86 (9.3%) | Â |
GO:0016052 carbohydrate catabolic process | mRNA | 1.37E-01 | 8/438 (1.8%) | 97/34273 (0.3%) |
| Â | Protein | 2.14E-04 | 6/86 (7.0%) | Â |
GO:0006006 glucose metabolic process | mRNA | 1.14E-03 | 18/899 (2.0%) | 161/34273 (0.5%) |
| Â | Protein | 3.80E-07 | 9/86 (10.5%) | Â |
GO:0006629 lipid metabolic process | mRNA | 1.60E-22 | 79/899 (8.8%) | 742/34273 (2.2%) |
| Â | Protein | 4.54E-11 | 19/86 (22.1%) | Â |
GO:0008610 lipid biosynthetic process | mRNA | 1.12E-18 | 48/899 (5.3%) | 324/34273 (0.9%) |
| Â | Protein | 2.14E-01 | 6/86 (7.0%) | Â |
GO:0016042 lipid catabolic process | Protein | 2.41E-07 | 9/86 (10.5%) | 153/34033 (0.4%) |
   GO:0006631 fatty acid metabolic process | mRNA | 2.93E-06 | 18/438 (4.1%) | 223/34273 (0.7%) |
| Â | Protein | 6.77E-13 | 14/86 (16.3%) | Â |
   GO:0008654 phospholipid biosynthetic process | mRNA | 1.29E-06 | 17/899 (1.9%) | 93/34273 (0.3%) |
GO:0008203 cholesterol metabolic process | mRNA | 1.05E-07 | 17/899 (1.9%) | 80/34273 (0.2%) |
   GO:0006695 cholesterol biosynthetic process | mRNA | 1.17E-05 | 10/899 (1.1%) | 30/34273 (0.1%) |
GO:0019538 protein metabolic process | mRNA | 4.58E-27 | 162/899 (18.0%) | 2325/34273 (6.8%) |
GO:0006412 ribosome translation | mRNA | 8.82E-13 | 53/899 (5.9%) | 347/34273 (1.0%) |
   GO:0006519 cellular amino acid and derivative metabolic process | mRNA | 5.13E-20 | 36/438 (8.2%) | 312/34273 (0.9%) |
| Â | Protein | 1.76E-19 | 20/86 (23.3%) | Â |
GO:0006508 proteolysis | mRNA | 2.57E-04 | 39/899 (4.3%) | 567/34273 (1.7%) |