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Table 1 Top Metabolic Processes Enriched in Transcriptomic and Proteomic Profiling of the Gcgr-/- Mouse Liver

From: Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

   Adj. p-value Sample frequency Background frequency
GO:0008152 metabolism Process mRNA 7.80E-80 438/899 (48.7%) 6938/34273 (20.2%)
  Protein 4.14E-29 70/86 (81.4%)  
   GO:0009058 biosynthetic process mRNA 2.32E-27 207/899 (23.0%) 3429/34273 (10.0%)
  Protein 3.67E-06 29/86 (33.7%)  
GO:0009056 catabolic process mRNA 4.59E-10 63/899 (7.0%) 839/34273 (2.4%)
  Protein 1.97E-20 31/86 (36.0%)  
GO:0005975 carbohydrate metabolic process mRNA 2.56E-05 36/899 (4.0%) 456/34273 (1.3%)
  Protein 1.71E-07 13/86 (15.1%)  
   GO:0016051 carbohydrate biosynthetic process mRNA 5.18E-04 11/438 (2.5%) 107/34273 (0.3%)
  Protein 4.38E-07 8/86 (9.3%)  
GO:0016052 carbohydrate catabolic process mRNA 1.37E-01 8/438 (1.8%) 97/34273 (0.3%)
  Protein 2.14E-04 6/86 (7.0%)  
GO:0006006 glucose metabolic process mRNA 1.14E-03 18/899 (2.0%) 161/34273 (0.5%)
  Protein 3.80E-07 9/86 (10.5%)  
GO:0006629 lipid metabolic process mRNA 1.60E-22 79/899 (8.8%) 742/34273 (2.2%)
  Protein 4.54E-11 19/86 (22.1%)  
GO:0008610 lipid biosynthetic process mRNA 1.12E-18 48/899 (5.3%) 324/34273 (0.9%)
  Protein 2.14E-01 6/86 (7.0%)  
GO:0016042 lipid catabolic process Protein 2.41E-07 9/86 (10.5%) 153/34033 (0.4%)
   GO:0006631 fatty acid metabolic process mRNA 2.93E-06 18/438 (4.1%) 223/34273 (0.7%)
  Protein 6.77E-13 14/86 (16.3%)  
   GO:0008654 phospholipid biosynthetic process mRNA 1.29E-06 17/899 (1.9%) 93/34273 (0.3%)
GO:0008203 cholesterol metabolic process mRNA 1.05E-07 17/899 (1.9%) 80/34273 (0.2%)
   GO:0006695 cholesterol biosynthetic process mRNA 1.17E-05 10/899 (1.1%) 30/34273 (0.1%)
GO:0019538 protein metabolic process mRNA 4.58E-27 162/899 (18.0%) 2325/34273 (6.8%)
GO:0006412 ribosome translation mRNA 8.82E-13 53/899 (5.9%) 347/34273 (1.0%)
   GO:0006519 cellular amino acid and derivative metabolic process mRNA 5.13E-20 36/438 (8.2%) 312/34273 (0.9%)
  Protein 1.76E-19 20/86 (23.3%)  
GO:0006508 proteolysis mRNA 2.57E-04 39/899 (4.3%) 567/34273 (1.7%)