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Table 5 Significantly Altered mRNA and Proteins related to Cholesterol and Bile Acid Metabolism

From: Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

  Transcriptomics Proteomics
Cholesterol synthesis Adj. p-value Fold change Adj. p-value Fold change
Acetyl-Coenzyme A acetyltransferase 2 (Acat2) 8.35E-03 2.1   
Farnesyl diphosphate farnesyl transferase 1 (Fdft1) 7.22E-03 1.9   
Farnesyl diphosphate synthetase (Fdps) 1.72E-02 1.7   
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1) 5.73E-03 1.6   
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2) 5.73E-03 1.3   
3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) 7.56E-03 3.0   
Isopentenyl-diphosphate delta isomerase (Idi1) 7.22E-03 2.4 4.46E-04 1.7
Lanosterol synthase (Lss) 6.52E-03 2.8   
NAD(P) dependent steroid dehydrogenase-like (Nsdhl) 1.38E-02 1.7   
Phosphomevalonate kinase (Pmvk) 1.23E-02 2.2   
Sterol O-acyltransferase 2 (Soat2) 4.33E-04 2.1   
SREBF chaperone (Scap) 3.97E-03 1.3   
Cholesterol Transport     
ATP-binding cassette, sub-family G (WHITE), member 5 (Abcg5) 6.99E-03 2.4   
ATP-binding cassette, sub-family G (WHITE), member 8 (Abcg8) 4.61E-03 1.8   
ATP-binding cassette, sub-family G (WHITE), member 1 (Abcg1) 2.88E-03 1.7   
Niemann Pick type C2 (Npc2) 1.13E-02 1.4   
Caveolin 1, caveolae protein (Cav1) 7.16E-03 4.6   
Apolipoprotein A-I (Apoa1) 3.45E-03 1.2   
Chemokine (C-X-C motif) ligand 16 (Cxcl16) 1.32E-02 1.4   
Scavenger receptor class B, member 1 (Scarb1) 6.98E-03 1.5   
Bile Acid Synthesis     
Cytochrome P450, family 7, subfamily B, polypeptide 1 (Cyp7b1) 3.45E-03 -3.1   
Cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1) 9.22E-04 -2.2   
Cytochrome P450, family 27, subfamily A, polypeptide 1 (Cyp27a1) 7.86E-03 1.4   
Cytochrome P450, family 39, subfamily a, polypeptide 1 (Cyp39a1) 3.73E-03 2.1   
Alpha-methylacyl-CoA racemase (Amacr) 2.01E-03 -1.4   
Sterol carrier protein 2, liver (Scp2) 1.18E-02 -1.2   
Bile acid-CoA:amino acid N-acyltransferase (Baat)    6.89E-04 1.3
Cysteine sulfinic acid decarboxylase (Csad)    7.17E-05 1.9
Hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4)    6.40E-04 1.7
Bile Acid Transport     
Sodium/bile acid cotransporter (Slc10a1) 7.40E-03 1.3   
ATP-binding cassette, sub-family B (MDR/TAP), member 11 (Abcb11) 3.04E-03 1.3   
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (Abcc3) 2.37E-03 1.6   
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (Abcc4) 8.85E-04 7.0   
Organic solute transporter beta (Ost) 7.12E-03 1.5