Figure 3
From: Evolutionarily conserved bias of amino-acid usage refines the definition of PDZ-binding motif
C-indexes of three-position-specified PB motifs derived from human x-x-S-x-V. (a and b) Expected patterns of the C-indexes of the three-position specified PB motifs when the AA compositions in the 'x' positions at C0 are different (a) or similar (b) to those at C1-C50, respectively. (c-e) Actual C-indexes of three-position specified PB motifs derived from human x-x-S-x-V. Additionally specified positions (-4 in c, -3 in d, -1 in e) in the three-position-specified PB motifs are indicated at the top of each panel with an [X]. Twenty AAs in single character code are indicated below the panels. The black filled circle in the most right column in each plot indicates the C-index of two-position-specified PB motifs, which is the same value as that shown in Figure 2. Values significantly lower than those of two-position-specified PB motifs are indicated with asterisks (Steel test, *P < 1.00E-4). Error bars indicate standard deviations. Actual values for each plot are shown in Additional file 5.