Table 1 List of biological processes GO categories enriched among genes differentially expressed in mineralizing VSa13 and VSa16 cells

protein homotetramerization

6

0.5

0.006

3.8

PROT. INTER.

protein tetramerization

7

0.5

0.013

2.9

protein homooligomerization

9

0.7

0.024

2.3

rRNA transcription

5

0.4

0.019

3.8

DNA/RNA METAB.

DNA replication

37

2.9

0.000

2.1

DNA-dependent DNA replication

19

1.5

0.001

2.1

serine family amino acid biosynt. process

6

0.4

0.025

2.9

vitamin biosynthetic process

10

0.8

0.003

2.7

hexose/alcohol/monosaccharide biosynthetic process

12

0.8

0.005

2.3

water-soluble vitamin biosynthetic process

9

0.7

0.008

2.6

BIOSYN. PROC.

amino acid biosynthetic process

15

1.0

0.043

1.7

hexose/alcohol/monosaccharide biosynthetic process

10

0.8

0.028

2.1

carbohydrate biosynthetic process

21

1.5

0.016

1.6

coenzyme biosynthetic process

21

1.6

0.012

1.7

nitrogen compound biosynthetic process

21

1.5

0.027

1.6

cofactor biosynthetic process

24

1.9

0.035

1.5

amine biosynthetic process

19

1.3

0.040

1.5

pigmentation

7

0.5

0.026

2.6

inner ear morphogenesis

7

0.5

0.045

2.4

fertilization

9

0.7

0.024

2.3

DEV.

tissue remodeling

14

1.1

0.009

2.0

embryonic morphogenesis

14

1.1

0.013

2.0

tissue development

33

2.5

0.005

1.6

embryonic development

33

2.5

0.010

1.5

mitochondrion organization and biogenesis

15

1.0

0.016

1.8

mitotic cell cycle checkpoint

9

0.7

0.024

2.3

cell motility/localization of the cell

59

4.1

0.002

1.4

cell cycle checkpoint

12

0.9

0.015

2.1

mitosis/M phase of mitotic cell cycle

35

2.4

0.024

1.4

regulation of mitosis

14

1.1

0.009

2.0

cell projection: morphogenesis,

28

2.0

0.040

1.4

growth

38

2.9

0.001

1.6

CELL CYCLE

organization and biogenesis

regulation of cell growth

18

1.4

0.042

1.6

AND

M phase

40

2.8

0.034

1.3

regulation of growth

25

1.9

0.018

1.5

GROWTH

cell division

36

2.5

0.041

1.3

cell growth

24

1.9

0.023

1.5

cell proliferation

89

6.2

0.013

1.2

regulation of cell size

24

1.9

0.035

1.5

cell motility/localization of the cell

52

4.0

0.007

1.4

mitosis/M phase of mitotic cell cycle

33

2.5

0.018

1.4

cell migration

31

2.4

0.027

1.4

mitotic cell cycle

43

3.3

0.039

1.3

cell proliferation

78

6.0

0.047

1.2

SIGNAL.

DNA damage response. signal transduction resulting in induction of apoptosis

5

0.3

0.028

3.4

phosphoinositide-mediated signaling

16

1.2

0.010

1.9

PROT.

tRNA modification

6

0.4

0.010

3.4

tRNA aminoacylation for protein translation/aminoacid activation

14

1.1

0.025

1.8

SYNT.

RNA modification

9

0.6

0.001

3.1

response to virus

14

1.0

0.003

2.2

response to wounding

50

3.9

0.006

1.4

STRESS

cell redox homeostasis

17

1.2

0.003

2.0

inflammatory response

32

2.5

0.049

1.4

RESP.

response to oxidative stress

19

1.3

0.040

1.5

response to stress

112

8.6

0.028

1.2

response to stimulus

216

15.1

0.011

1.1

response to stimulus

194

15.0

0.026

1.1

ADH.

biological/cell adhesion

65

5.0

0.026

1.3

BIOL. REG.

regulation of biological quality

103

7.2

0.018

1.2

regulation of biological quality

97

7.5

0.008

1.2

isoprenoid metabolic process

9

0.6

0.015

2.4

purine ribonucleoside metabolic process

5

0.4

0.019

3.8

glutathione metabolic process

8

0.6

0.033

2.3

ribonucleoside/glycine metabolic process

6

0.5

0.017

3.2

pyruvate metabolic process

11

0.8

0.017

2.1

retinoid/diterpenoid metabolic process

5

0.4

0.046

3.1

gluconeogenesis

9

0.6

0.043

2.1

aldehyde metabolic process

6

0.5

0.035

2.8

mitochondrial transport

12

0.8

0.032

1.9

serine family amino acid metabolic process

12

0.9

0.002

2.5

sulfur metabolic process

17

1.2

0.010

1.8

glutamine family amino acid metab. process

12

0.9

0.004

2.4

water-soluble vitamin metabolic process

13

0.9

0.049

1.7

nucleoside/pyridine nucleotide metab. process

10

0.8

0.011

2.4

glucose metabolic process

26

1.8

0.010

1.6

water-soluble vitamin metabolic process

16

1.2

0.001

2.3

glucose catabolic process

17

1.2

0.037

1.6

gluconeogenesis

9

0.7

0.024

2.3

vitamin/alcohol metabolic process

18

1.3

0.039

1.6

oxygen and ROS metabolic process

8

0.6

0.033

2.3

nucleotide metabolic process

47

3.3

0.001

1.5

vitamin metabolic process

23

1.8

0.000

2.2

nucleobase. nucleoside and nucleotide metabolic process

49

3.4

0.002

1.5

pyruvate metabolic process

10

0.8

0.028

2.1

monosaccharide metabolic process

32

2.2

0.016

1.5

glucose metabolic process

26

2.0

0.002

1.8

carboxylic/organic acid metab. process

102

7.1

0.000

1.4

glucose catabolic process

17

1.3

0.015

1.8

amino acid and derivative metabolic process

67

4.7

0.002

1.4

amino acid catabolic process

15

1.2

0.025

1.8

amino acid metabolic process

54

3.8

0.008

1.4

alcohol catabolic process

18

1.4

0.015

1.7

monocarboxylic acid metabolic process

45

3.1

0.015

1.4

hexose/monosaccharide catabolic process

17

1.3

0.026

1.7

hexose metabolic process

31

2.2

0.023

1.4

amine/nitrogen compound catabolic process

16

1.2

0.034

1.7

fatty acid metabolic process

31

2.2

0.034

1.4

monosaccharide metabolic process

31

2.4

0.007

1.6

METAB.

lipid biosynthetic process

32

2.2

0.040

1.4

aromatic compound metabolic process

23

1.8

0.012

1.6

amine metabolic process

74

5.2

0.006

1.3

carbohydrate catabolic process

21

1.6

0.025

1.6

nitrogen compound metabolic process

75

5.2

0.010

1.3

tRNA metabolic process

19

1.5

0.026

1.6

alcohol metabolic process

47

3.3

0.021

1.3

cellular carbohydrate catabolic process

20

1.5

0.032

1.6

cellular carbohydrate metabolic process

52

3.6

0.036

1.3

amino acid metabolic process

54

4.2

0.001

1.5

catabolic process

106

7.4

0.012

1.2

nucleobase. nucleoside and nucleotide metabolic process

46

3.5

0.001

1.5

lipid metabolic process

85

5.9

0.012

1.2

nucleotide metabolic process

42

3.2

0.003

1.5

cellular lipid metabolic process

69

4.8

0.037

1.2

coenzyme metabolic process

37

2.9

0.011

1.5

hexose metabolic process

30

2.3

0.011

1.5

carboxylic/organic acid metabolic process

97

7.5

0.000

1.4

amine metabolic process

72

5.6

0.001

1.4

amino acid and derivative metabolic process

62

4.8

0.002

1.4

nitrogen compound metabolic process

73

5.6

0.002

1.4

cofactor metabolic process

46

3.5

0.007

1.4

cellular carbohydrate metabolic process

51

3.9

0.009

1.4

carbohydrate metabolic process

67

5.2

0.009

1.3

alcohol metabolic process

43

3.3

0.026

1.3

cellular catabolic process

84

6.5

0.017

1.2

catabolic process

95

7.3

0.027

1.2

lipid metabolic process

75

5.8

0.037

1.2

cellular lipid metabolic process

63

4.9

0.043

1.2

bone mineralization

6

0.5

0.035

2.8

BONE

ossification/biomineral formation/bone remodelling

13

1.0

0.011

2.0

skeletal development

28

2.2

0.009

1.6